Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Hepatitis E virus (HEV) is the leading cause of acute hepatitis worldwide. While the transmission in developing countries is dominated by fecal-oral route via drinking contaminated water, the zoonotic transmission is the major route of HEV infection in industrialized countries. The discovery of new HEV strains in a growing number of animal species poses a risk to zoonotic infection. However, the exact mechanism and the determinant factors of zoonotic infection are not completely understood. This review will discuss the current knowledge on the mechanism of cross-species transmission of HEV infection, including viral determinants, such as the open reading frames (ORFs), codon usage and adaptive evolution, as well as host determinants, such as host cellular factors and the host immune status, which possibly play pivotal roles during this event. The pathogenesis of hepatitis E infection will be briefly discussed, including the special forms of this disease, including extrahepatic manifestations, chronic infection, and fulminant hepatitis in pregnant women.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157021 | PMC |
| http://dx.doi.org/10.3390/v13050909 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Bacterial Glutamine Synthetases as a Novel Metabolic Selection Marker to Improve CHO Cell Culture Performance Through Selection Stringency Modulation.
Biotechnol J
September 2025
Bioprocess Development Biologicals, Cell Line Development, Boehringer Ingelheim GmbH & Co. KG, Biberach, Germany.
The use of metabolic selection markers has advanced stable cell line generation, increasing productivity while simultaneously eliminating the need for antibiotic reagents. This study explores the potential of bacterially derived glutamine synthetases (GS) as a novel generation of metabolic selection markers to further enhance CHO cell culture performance. GS-I proteins were extracted from the genomes of enterobacterial and actinomycetes species.
View Article and Find Full Text PDFAlcohol use disorder-associated pain: clinical and preclinical evidence.
Alcohol
September 2025
School of Neuroscience, Virginia Polytechnic and State University, 970 Washington Street SW, Blacksburg, VA, 24061, USA. Electronic address:
Alcohol Use Disorder (AUD) affects millions of people globally and is characterized by cycles of intoxication, withdrawal, and relapse. Convergent clinical and preclinical evidence strongly support the conclusion that AUD precipitates chronic pain marked by mechanical and thermal hypersensitivity, yet currently available FDA-approved therapeutics do not effectively manage AUD-associated pain. This review synthesizes clinical and preclinical evidence on AUD-associated pain, highlighting known phenomena of allodynia and hyperalgesia as well as small and/or large fiber neuropathy in patient subpopulations along with preclinical acute and chronic alcohol exposure paradigm-specific nociceptive phenotypes in rodents.
View Article and Find Full Text PDFNMOD: A Multi-Dimensional Omics Database for Disease Resistance Research in Nicotiana.
Plant Cell Physiol
September 2025
Agricultural Big-Data Research Center and College of Plant Protection, Shandong Agricultural University, Tai'an, 271018, China.
High-throughput sequencing has generated extensive omics data for Nicotiana species, a key model genus in the Solanaceae family. However, fragmented data and limited cross-species integration in current databases hinder the identification of disease-resistant genes and germplasm innovation. To address these challenges, we developed Nicotiana Multi-Dimensional Omics Database (http://biodb.
View Article and Find Full Text PDFEmerging Viral Threats in Rice: A Decade of Discovery and Implications for Crop Protection.
Plant Cell Environ
September 2025
State Key Laboratory of Agricultural and Forestry Biosecurity, Institute of Plant Virology, Vector-Borne Virus Research Center, Fujian Agriculture and Forestry University, Fuzhou, China.
Rice viral diseases pose severe threats to global food security, with over 20 viruses identified in China alone. The advent of high-throughput sequencing has accelerated the discovery of novel viruses in cultivated and wild rice, unveiling previously undetected threats. This review systematically summarises newly discovered rice viruses over the past decade, analyzing their genomic characteristics, transmission modes, and pathogenic mechanisms.
View Article and Find Full Text PDFEvolutionary trajectory estimation via replication simulation of coronavirus spike gene based on random mutation and similarity-based selection.
Comput Struct Biotechnol J
August 2025
Department of Biological Sciences and Biotechnology, College of Natural Science, Chungbuk National University, Cheongju, Republic of Korea.
Viruses exhibit rapid evolutionary dynamics through random mutations and selection, driving their adaptation and cross-species transmission. To investigate these mechanisms, we designed a simulation framework with a graphical user interface (GUI), implementing random mutation and similarity-based selection. This system models the evolution of a user-supplied viral sequence toward a designated target by recursively selecting the top-N amino acid sequences with the greatest similarity in each replication cycle.
View Article and Find Full Text PDF