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Article Abstract
The phytochemical investigation of the twig and root extracts of (Hassk.) Merr. (Fabaceae) resulted in the isolation and identification of a new pterocarpan, erythrinocarpan (), along with 27 known compounds (-). All isolated compounds were evaluated for their antidiabetic, antimicrobial, and anti-inflammatory properties. Compounds , , , and had α-glucosidase inhibitory activity with IC values of 13.4 ± 0.05, 24.5 ± 0.13, 29.0 ± 0.05, and 12.8 ± 0.14 μM, respectively, while compound inhibited α-amylase activity with an IC value of 67.6 ± 1.12 μM. Compounds and inhibited glycation activity with the IC values of 36.9 ± 0.62 and 40.5 ± 0.37 μM, respectively. From cell-based assays, compound showed the highest ability to induce glucose consumption (IC 29.1 ± 0.86 μM) and glucose uptake (2.8-fold), and to inhibit nitric oxide (NO) production (IC 52.5 ± 0.56 μM) without cell toxicity. Furthermore, compound showed antimicrobial activities against Gram-positive bacteria and fungi with MIC values ranging from 2-4 μg/mL.
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| http://dx.doi.org/10.1016/j.heliyon.2021.e06904 | DOI Listing |
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