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http://dx.doi.org/10.1016/j.resmer.2021.100821 | DOI Listing |
Clin Cosmet Investig Dermatol
August 2025
Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Methotrexate (MTX) is widely utilized for the management of autoimmune diseases and neoplasms. It may cause several adverse effects, including myelosuppression, hepatitis, and mucositis, and in rare cases, can result in cutaneous vasculitis. We present a case involving a 60-year-old female patient receiving 5 milligrams (mg) of MTX weekly for the treatment of systemic lupus erythematosus (SLE).
View Article and Find Full Text PDFHNO
September 2025
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital and University of Zurich, Zurich, Switzerland.
Eosinophilic granulomatosis with polyangiitis (EGPA, previously known as Churg-Strauss syndrome) is an antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) often presenting with chronic rhinosinusitis, pulmonary infiltrates, gastrointestinal and cardiac disorders, or renal lesions. Sinonasal and inner ear manifestations are common, but other affections of the head and neck area are rarely reported. Here we report a case of a young woman with a histopathological diagnosis of eosinophil-rich granulomatous inflammation affecting solely the tongue without other local or systemic lesions.
View Article and Find Full Text PDFACR Open Rheumatol
September 2025
University of Pennsylvania, Philadelphia.
Objective: In the phase 3 head-to-head MANDARA study (NCT04157348), benralizumab demonstrated noninferiority to mepolizumab in inducing remission (defined as Birmingham Vasculitis Activity Score [BVAS] of 0 and oral glucocorticoid [OGC] dosage ≤4 mg/day at weeks 36 and 48) in patients with eosinophilic granulomatosis with polyangiitis (EGPA). This analysis investigated a more stringent definition of remission that included discontinuation of OGCs and being relapse-free.
Methods: Patients aged ≥18 years with documented relapsing or refractory EGPA receiving OGCs at ≥7.
Reumatol Clin (Engl Ed)
August 2025
Grupo Peruano de Estudio de Enfermedades Autoinmunes Sistémicas, Universidad Científica del Sur, Lima, Peru; Servicio de Reumatología, Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, Lima, Peru. Electronic address:
Objective: To determine the factors associated with health-related quality of life (HRQoL) in adult patients with ANCA-associated vasculitis (AAV).
Methodology: An observational, analytical, retrospective study was conducted using a convenience sampling technique. Data were obtained from the Almenara Vasculitis Cohort during the period from December 2022 to December 2023.
Int J Mol Sci
August 2025
Department of Pathology, "C.I. Parhon" National Institute of Endocrinology, 011863 Bucharest, Romania.
Riedel thyroiditis (RT) is a rare immune-mediated inflammatory disease that destroys the thyroid parenchyma, replacing it with storiform fibrosis extending to the extrathyroidal tissue. Secondary fibrotic lesions can be associated as parts of the systemic IgG4-related disease. We present the case of a 52-year-old female patient who presented initially with subacute thyroiditis when corticosteroid treatment was initiated.
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