Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The shugoshin proteins are universal protectors of centromeric cohesin during mitosis and meiosis. The binding of human hSgo1 to the PP2A-B56 phosphatase through a coiled-coil (CC) region mediates cohesion protection during mitosis. Here we undertook a structure function analysis of the PP2A-B56-hSgo1 complex, revealing unanticipated aspects of complex formation and function. We establish that a highly conserved pocket on the B56 regulatory subunit is required for hSgo1 binding and cohesion protection during mitosis in human somatic cells. Consistent with this, we show that hSgo1 blocks the binding of PP2A-B56 substrates containing a canonical B56 binding motif. We find that PP2A-B56 bound to hSgo1 dephosphorylates Cdk1 sites on hSgo1 itself to modulate cohesin interactions. Collectively our work provides important insight into cohesion protection during mitosis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256288 | PMC |
| http://dx.doi.org/10.15252/embr.202052295 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cognitive Impairment and Contexts: Examining the Intersections of Social Activity Participation and Neighborhood Perceptions.
J Gerontol B Psychol Sci Soc Sci
September 2025
Institute of Gerontology, Wayne State University, Detroit, Michigan, United States.
Objectives: In this study, we examined the extent to which older adult social activity participation and perceptions of neighborhoods correspond with risks of cognitive impairment and no dementia (CIND) and dementia.
Methods: We predicted the risk of both CIND and dementia in a series of Cox proportional hazards analyses among older adults across a ten-year period. Utilizing data from the Health and Retirement Study (HRS, N = 15,020), we examined whether social activity participation corresponded with reduced risk of CIND and dementia, as well as whether perceptions of neighborhood conditions, social cohesion, and neighborhood disorder moderated the effects of social activity participation.
Our Challenges, Our Solutions: The Impact of Autism on Families.
J Autism Dev Disord
September 2025
Institute of Child Protection Studies, Australian Catholic University, 223 Anthill Street, Canberra, 2602, Australia.
This study investigated how autism impacts the relationships between family members and the family unit. It aimed to provide a deeper qualitative understanding by incorporating the perspectives of autistic adolescents and their family members, adding depth to existing quantitative findings. This qualitative study involved audio-recorded semi-structured in-depth interviews with 40 participants, including mothers, fathers, siblings, and autistic adolescents, recruited through autism and disability agencies in Canberra, Australia.
View Article and Find Full Text PDFMeso-organisational determinants of healthcare workers' resilience: results of a scoping review.
Health Policy
August 2025
MRM, University of Montpellier, Montpellier, France. Electronic address:
Background: Recent financial, environmental, and health crises have underscored the critical-but often overlooked-role of healthcare workers (HCWs) for health system resilience. Given the ongoing physical and psychological demands placed on this workforce, understanding the factors that influence their resilience is essential.
Objective: This scoping review aimed to map and synthesise multidisciplinary evidence on meso-level organisational factors that influence individual resilience among HCWs.
Meibum - a lipid-rich secretion produced by holocrine Meibomian glands (MG) - plays a central role in maintaining ocular surface homeostasis. Previously, changes in MG lipidomes induced by inactivation of critical genes of meibogenesis, such as and others, were shown to cause MG-dysfunction- and dry eye-like signs in mice. Here, we describe the impact of the lipid composition of meibum on its physiological properties, specifically thermotropic/melting characteristics, using various wild type and mutant animals, and compare them with meibum of healthy humans and patients with abnormal meibum.
View Article and Find Full Text PDFThe mediating role of family adaptability in the relationship between insecure attachment and family functioning in patients with major depression disorder: a cross-sectional study.
Front Psychiatry
August 2025
Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Introduction: Depression ranks as the second leading cause of the global health burden; therefore, identification of its risk and influencing factors is essential to develop more effective multidimensional interventions. The aim of the present study was to analyze the mediating role of family adaptability (FA) on the relationship between insecure attachment (IA) and family functioning (FF) in patients with major depressive disorder (MDD), which currently remains unclear. It also aims to provide a theoretical reference for optimizing rehabilitation interventions.
View Article and Find Full Text PDF