Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Whereas humans and other adult mammals lack the ability to regain locomotor function after spinal cord injury, zebrafish are able to recover swimming behavior even after complete spinal cord transection. We have previously shown that zebrafish larvae regenerate lost spinal cord neurons within 9 days post-injury (dpi), but it is unknown whether these neurons are physiologically active or integrate into functional circuitry. Here we show that genetically defined premotor interneurons are regenerated in injured spinal cord segments as functional recovery begins. Further, we show that these newly-generated interneurons receive excitatory input and fire synchronously with motor output by 9 dpi. Taken together, our data indicate that regenerative neurogenesis in the zebrafish spinal cord produces interneurons with the ability to integrate into existing locomotor circuitry.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.expneurol.2021.113737 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Role of Deep Cerebral Tracts in Predicting Postoperative Aphasia: An nTMS-Based Investigation of the Corticothalamic Fibers.
Hum Brain Mapp
September 2025
Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.
Postoperative aphasia (POA) is a common complication in patients undergoing surgery for language-eloquent lesions. This study aimed to enhance the prediction of POA by leveraging preoperative navigated transcranial magnetic stimulation (nTMS) language mapping and diffusion tensor imaging (DTI)-based tractography, incorporating deep learning (DL) algorithms. One hundred patients with left-hemispheric lesions were retrospectively enrolled (43 developed postoperative aphasia, as the POA group; 57 did not, as the non-aphasia (NA) group).
View Article and Find Full Text PDFCognitive Compensation Depends on Frontoparietal Network Structure-Function Coupling in Patients With White Matter Hyperintensity.
Brain Behav
September 2025
Department of Neurology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
Background And Purpose: White matter hyperintensity (WMH) impairs cognitive function but is not evident in the early stage, raising the need to explore the underlying mechanism. We aimed to investigate the potential role of network structure-function coupling (SC-FC coupling) in cognitive performance of WMH patients.
Methods: A total of 617 participants with WMH (mean age = 61 [SD = 8]; 287 females [46.
Brain Microstructural Alteration and Its Implications for Postoperative Delirium in Elderly Surgical Patients: A Narrative Review.
Brain Behav
September 2025
Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai, China.
Purpose: Postoperative delirium (POD) remains poorly understood in terms of predictors and underlying mechanisms. This review summarized emerging evidence on the association between brain microstructural alterations and POD.
Method: This is a narrative review, describing the microstructural changes in aging brain, microstructural MRI findings, relationship among microstructural alterations, cognitive reserve and POD, and potential interventions targeting microstructure.
Tissue bridges offer valuable insights into bladder and bowel outcomes in chronic cervical spinal cord injury.
Eur Spine J
September 2025
Department of Spine Surgery, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Purpose: This study aimed to investigate the relationship between tissue bridges and bladder and bowel outcomes in chronic cervical spinal cord injury (SCI).
Methods: Between July 2020 and January 2024, 44 patients with chronic cervical SCI were retrospectively included in this cross-sectional study at a specialized SCI center. Lesion severity was assessed by tissue bridges, lesion length, lesion width, and lesion area.
Astrocytic monoamine oxidase B (MAOB)-gamma-aminobutyric acid (GABA) axis as a molecular brake on repair following spinal cord injury.
Signal Transduct Target Ther
September 2025
Spine & Spinal Cord Institute, Department of Neurosurgery, College of Medicine, Yonsei University, Seoul, Republic of Korea.
Neuroregeneration and remyelination rarely occur in the adult mammalian brain and spinal cord following central nervous system (CNS) injury. The glial scar has been proposed as a major contributor to this failure in the regenerative process. However, its underlying molecular and cellular mechanisms remain unclear.
View Article and Find Full Text PDF