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Article Abstract
Objective: The purpose of this study was to investigate the morphological changes of round window membrane (RWM) in chinchillas with serotype 7F induced acute otitis media (AOM) by two dimensional (2D) and three dimensional (3D) measurements.
Methods: Temporal bone specimens taken from 12 chinchillas were divided into two groups. The control group consisted of healthy animals that were injected with intrabullar saline. The subjects in the experimental group were induced with AOM by intrabullar injection of 7F. The 2D and 3D measurements of RWM were compared between the groups.
Results: Dramatic changes were noted in the RWM of the experimental group compared to the control group. The thickness [mean ± standard deviation (SD)] of the RWM was significantly (p<0.05) increased in the experimental group compared to the control group by 2D measurements taken at three different points of RWM. Moreover, 3D measurements revealed that the volume (mean ± SD) of RWM was significantly (p=0.009) increased in the experimental group.
Conclusion: The results of our study, which indicated significant change in RWM in both 2D and 3D measurements, may shed light on the relationship between AOM and inner ear diseases. Based on our results, we recommend evaluating 3D analyses of RWM, which provide useful data, to better understand the changes in the membrane.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054926 | PMC |
| http://dx.doi.org/10.4274/tao.2021.5998 | DOI Listing |
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