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Background: The fish is endemic to the Upper Gulf of California. Its migratory movements involve sites with high levels of trace elements in the environment that can accumulate in tissues. In this study, lead (Pb), copper (Cu), cadmium (Cd), zinc (Zn) and iron (Fe) concentrations in male and female totoaba liver and muscle were quantified at various sexual maturity stages along the species' geographic distribution.
Methods: Generalized linear models were used to explore associations between trace element concentrations and season of the year, sex/maturity stage, and total fish length.
Results: No detectable Pb concentrations were recorded in liver or muscle; Cu, Cd, Zn and Fe contents in totoaba liver and muscle were typical of fish inhabiting areas with no contamination issues and are within international maximum permissible levels for human consumption. Variations in the content of Cd, Cu, Zn and Fe in liver of totoaba seem to be more related to the feeding and reproductive physiology of this species than as result of environmental exposure. Results suggest that consumption of totoaba muscle does not pose a public health risk. Furthermore, depending on the sex/maturity stage of totoaba, this fish's muscle may provide approximately 70% Cu, 60% Zn and 100% Fe of the recommended dietary reference intake.
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http://dx.doi.org/10.7717/peerj.11068 | DOI Listing |
Inflamm Bowel Dis
September 2025
Pediatric Gastroenterology, Hepatology and Cystic Fibrosis Unit, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico di Milano, Milan, Italy.
Background: The effect of sarcopenia on clinical outcomes in children with Crohn's disease (CD) is unknown. We investigated whether sarcopenia at the diagnosis impacts the outcomes of children with CD.
Methods: This was a retrospective, single-center, case-control study of newly diagnosed children with CD undergoing magnetic resonance (MR) within 1 month from the diagnosis, from 2011 to 2022.
J Lipid Res
September 2025
Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address:
In an interplay with parenchymal cells of metabolically active organs such as heart and adipose tissues, vascular endothelial cells are important for the regulation of nutrient uptake and organ-specific energy metabolism. Based on high expression of the scavenger receptor B1 (SR-B1) in capillary endothelial cells of white and brown adipose tissue (BAT), we proposed a functional role for this receptor in lipid handling and adaptive thermogenesis. To address this hypothesis, we generated mice with an endothelial-specific knockout of SR-B1 and performed metabolic turnover and indirect calorimetry studies in response to environmental cues such as cold exposure and high fat diet feeding.
View Article and Find Full Text PDFSci Adv
September 2025
School of Engineering and Materials Science, Queen Mary University of London, UK.
During heart disease, the cardiac extracellular matrix (ECM) undergoes a structural and mechanical transformation. Cardiomyocytes sense the mechanical properties of their environment, leading to phenotypic remodeling. A critical component of the ECM mechanosensing machinery, including the protein talin, is organized at the cardiomyocyte costamere.
View Article and Find Full Text PDFEur Heart J
September 2025
Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
Cardiovascular disease remains a major global health challenge, with dyslipidaemia being a key modifiable risk factor. While low density lipoprotein cholesterol (LDL-C) is the primary target for lipid-lowering therapies, recent evidence highlights the importance of triglycerides, apolipoprotein B (apoB), and lipoprotein(a) [Lp(a)] for residual cardiovascular risk. Current lipid-lowering therapies target key enzymes and proteins involved in cholesterol and lipid metabolism.
View Article and Find Full Text PDFAvian Pathol
September 2025
North of England Zoological Society (Chester Zoo), Chester, UK.
Avian pseudotuberculosis infection usually presents as well-demarcated visceral necrotic foci, typically affecting the gastrointestinal tract, liver and spleen. This case series describes an atypical presentation of (Yptb) characterized by severe chronic myositis, arthritis and osteomyelitis in five village weavers (), and acute osteomyelitis and myositis associated with septicaemia in an oriental magpie robin () from a zoological collection. Clinical signs of the weavers included lethargy, poor flying ability and focally extensive periarticular and muscular swelling, whereas the magpie robin was found dead without premonitory signs.
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