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Article Abstract
Erythro-myeloid progenitors (EMP) are found in a population of cells expressing CD31 and CD45 markers (CD31CD45). A recent study indicated that EMPs persist until adulthood and can be a source of endothelial cells. We identified two sub-populations of EMP cells, CD31CD45 and CD31CD45, from peripheral blood that can differentiate into cells of erythroid lineage. Our novel findings add to the current knowledge of hematopoietic lineage commitment, and our sequential, dual-step, in vitro culture model provides a platform for the study of the molecular and cellular mechanisms underlying human hematopoiesis and erythroid differentiation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042691 | PMC |
| http://dx.doi.org/10.1186/s13287-021-02311-y | DOI Listing |
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