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http://dx.doi.org/10.1016/j.cell.2021.03.010 | DOI Listing |
Front Pharmacol
August 2025
Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Osteoporosis (OP) is a serious public health issue, and fragility fractures resulting from OP are a major cause of death in the elderly. Osteoblast (OB)-mediated insufficient bone formation and osteoclast (OCs)mediated abnormalities in bone destruction can result in OP. Autophagy is the process by which cells degrade and recycle their own proteins and organelles.
View Article and Find Full Text PDFFuture Med Chem
July 2025
State Key Laboratory of Oral Diseases, West China School of Stomatology, National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, China.
Cathepsin K (Cat K) is a member of the Cathepsin family and is found in a wide range of tissues. Cat K is involved in the terminal catabolism and recycling of endocytosed proteins, as well as specific cellular processes and a wide range of diseases. It is predominantly expressed in osteoclasts and has potent collagenase activity.
View Article and Find Full Text PDFJCI Insight
July 2025
Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, United States of America.
Autophagy is a recycling pathway in which damaged proteins, protein aggregates, and organelles are delivered to lysosomes for degradation. Autophagy insufficiency is thought to contribute to osteoporosis. Accordingly, autophagy elimination from the osteoblast lineage reduces bone formation and bone mass.
View Article and Find Full Text PDFInt J Mol Sci
June 2025
Brodie Tooth Development Genetics & Regenerative Medicine Research Laboratory, Department of Oral Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.
Autophagy is a cellular process that recycles intracellular macromolecules and degrades toxic cytoplasmic material to provide the cell with nutrients and facilitate survival. Although autophagy and its role in the differentiation of osteoblasts, osteoclasts, and odontoblasts has been described, the importance of autophagy during matrix mineralization remains unaddressed. This review aims to characterize the autophagy/matrix mineralization relationship and elucidate the significance of autophagy during matrix mineralization.
View Article and Find Full Text PDFMol Med
June 2025
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Luoyu Road #237, Hongshan District, Wuhan, 430079, China.
Orthodontics aims to correct misaligned teeth by repositioning them into their proper three-dimensional positions through periodontal remodeling triggered by orthodontic forces. Orthodontic tooth movement (OTM) is an aseptic inflammation process characterized by osteoclast-mediated bone resorption on the compression side and osteoblast-induced bone deposition on the tension side. Orthodontic forces primarily include compressive force (CF), tensile force (TF), and flow shear stress (FSS), meanwhile, hypoxia is concomitantly induced during force application.
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