98%
921
2 minutes
20
Stress sensitivity in reservoirs is critical during the exploitation of oil and gas fields. As a deep clastic reservoir under strong tectonic compression, the Ahe Formation in the northern tectonic zone of the Kuqa depression exhibited strong stress sensitivity effect. However, the conventional evaluation method by using permeability damage rate as a constraint restricts the mechanistic understanding of the strong stress sensitivity effect. In this study, morphology of stress sensitivity test curve, coupled with rate change of permeability and extent of irreversible damage in actual sample measurement through micro-CT in-situ scanning, is used to characterize differentially. The strong stress sensitivity effects of the studied intervals can be divided into three types: (1) rapid change in permeability-weak irreversible damage, (2) moderate change in permeability-strong irreversible damage and (3) moderate change in permeability-moderate irreversible damage. The strong stress sensitivity is caused by the micro-pores and micro-fractures, which are widely developed in the studied reservoir. The mechanisms caused by the two types of pore are different. The stress sensitivity effects in micro-fracture-rich reservoirs are characterized by rapid change in permeability and weak irreversible damage. Meanwhile, the stress sensitivity effects in micro-pore-rich reservoirs are manifested as moderate change in permeability and strong irreversible damage. The study shows that the differences in the content of micro-pores and micro-fractures and their reverse mechanisms of stress sensitivity co-create different types of stress sensitivity within the samples. Accordingly, the differences of the stress sensitivity type in macroscopic samples are caused by the competition between the microscopic differences of pore types.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016854 | PMC |
http://dx.doi.org/10.1038/s41598-021-86444-3 | DOI Listing |
Clin Epigenetics
September 2025
Department of Psychiatry and Psychotherapy, Philipps University Marburg, Marburg, Germany.
Background: Work-related stress is a well-established contributor to mental health decline, particularly in the context of burnout, a state of prolonged exhaustion. Epigenetic clocks, which estimate biological age based on DNA methylation (DNAm) patterns, have been proposed as potential biomarkers of chronic stress and its impact on biological aging and health. However, their role in mediating the relationship between work-related stress, physiological stress markers, and burnout remains unclear.
View Article and Find Full Text PDFEnviron Sci Technol
September 2025
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P.R. China.
Ambroxol (AMB), a common expectorant, enters aquatic environments via wastewater, yet its ecological risks remain unclear. Under UV exposure (15 mJ·cm, λ = 185-400 nm), AMB undergoes photolysis, among the photoproducts, 4-((2-amino-3-bromobenzyl)amino) cyclohexanol (P1) and 2-amino-3,5-dibromobenzaldehyde (DBA) are major species, comprising over 50% of the total photoproduct peak area at the photolytic plateau. Acute toxicity tests with AMB, P1, and DBA in four aquatic species at different trophic levels revealed: the highest sensitivity in (LC = 0.
View Article and Find Full Text PDFMed Eng Phys
October 2025
Department of Mechanical Engineering, University of Cape Town, 7701, South Africa; Centre for Research in Computational and Applied Mechanics (CERECAM), University of Cape Town, 7701, South Africa.
The usability and versatility of autoinjectors in managing chronic and autoimmune diseases have made them increasingly attractive in medicine. However, investigations into autoinjector designs require an understanding of the kinematic properties and fluid behaviour during injection. To optimise injection efficiency, this study develops a mathematical and computational fluid dynamics (CFD) model of an IM autoinjector by investigating the effects of viscosity, needle length, needle diameter, and medication volume on the injection process.
View Article and Find Full Text PDFInt J Pharm
September 2025
Laboratory of Advanced Theranostic Materials and Technology, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, PR China; Zhejiang International Scientific and Technological Cooperative Base of Biomedical Materials and Technology, Ningbo Cixi Instit
Smart hydrogels have advanced rapidly in recent years. However, systems responsive to a single stimulus are typically triggered by specific cues, limiting their adaptability in complex and dynamic biological environments. To overcome this limitation, this study developed a dual-responsive hydrogel sensitive to both temperature and mechanical stress.
View Article and Find Full Text PDFClin Chim Acta
September 2025
Department of Physiology, University of Louisville, Louisville 40202 KY, USA. Electronic address:
Diabetic nephropathy (DN) is a major cause of end-stage renal disease, with podocyte injury representing an early pathogenic event. Conventional biomarkers such as albuminuria and eGFR identify renal damage only at advanced stages, limiting opportunities for timely intervention. Wilms' Tumor 1 (WT1), a podocyte-specific transcription factor, has emerged as a sensitive marker of early glomerular stress.
View Article and Find Full Text PDF