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Purpose: To evaluate the clinical outcomes of cataract surgery with implantation of a novel model of extended depth of focus (EDOF) intraocular lens (IOL).
Methods: Pilot case series enrolling a total of 27 eyes of 16 patients (49 to 84 years) undergoing uncomplicated phacoemulsification cataract surgery with implantation of the EDOF IOL Synthesis PLUS (Cutting Edge, Montpellier, France). Near (UNVA, uncorrected near visual acuity; DCNVA, distance-corrected near visual acuity) and distance visual acuity (uncorrected and corrected distance visual acuity, UDVA and CDVA), monocular defocus curve and refractive outcomes were evaluated during a 3-month follow-up.
Results: Mean postoperative UDVA, UNVA and DCNVA were 0.11±0.17, 0.14±0.22 and 0.37±0.36 logMAR, respectively. A total of 84.6%, 91.7%, and 96.3% of eyes achieved postoperative UDVA, UNVA and CDVA of 0.20 logMAR or better. A total of 78.6% of eyes achieved postoperative DCNVA of 0.30 logMAR or better. Mean postoperative spherical equivalent was -0.76±0.53 D. The distance-corrected visual acuity was maintained on average over a value of 0.30 logMAR for the range of defocus levels between +1.00 and -1.50 D.
Conclusion: The implantation of the Synthesis plus EDOF IOL after cataract surgery seems to provide functional levels of distance, intermediate and near visual acuity. The near visual performance with this new IOL might be significantly enhanced using a micro-monovision approach. The results of this pilot study should be confirmed in future clinical trials.
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http://dx.doi.org/10.2147/OPTH.S297985 | DOI Listing |
Graefes Arch Clin Exp Ophthalmol
September 2025
Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Hospital, No. 1 Shuaifuyuan Wangfujing Dongcheng District, China, 100730, Beijing.
Purpose: To evaluate the predictive value of the preoperative orientation and offset of angle alpha(chord alpha) and angle kappa(chord mu) for visual outcomes in patients who underwent trifocal intraocular lens (IOL) implantation.
Methods: Patient records of eyes that underwent AT LISA tri 839MP implantation were retrospectively collected and grouped according to the preoperative offset and orientations of chord alpha and chord mu. The two-dimensional location of each angle was described by the interaction of the orientation and offset.
Retin Cases Brief Rep
October 2024
Eye Clinic, Humanitas-Gradenigo Hospital, Torino, Italy.
Purpose: To study the efficacy and safety of pro re nata regimen of brolucizumab, without loading dose, in treatment-naive patients with neovascular age-related macular degeneration (nAMD).
Case Series: Retrospective, observational study. We included all consecutive patients diagnosed with treatment- naïve nAMD undergoing Brolucizumab in Humanitas eye clinic, Turin, Italy between April 2022 and May 2023.
J Ophthalmic Vis Res
September 2025
Clinical Research Development Unit, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran.
Purpose: To evaluate the time required for refractive error (RE) stabilization after standard phacoemulsification cataract surgery and identify preoperative factors influencing this duration.
Methods: This prospective case series study enrolled patients who had undergone phacoemulsification cataract surgery. RE stabilization was defined as 0.
Front Med (Lausanne)
August 2025
Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Purpose: To investigate the mechanism, intraoperative characteristics, management, and prevention of incision capsular bag herniation (ICBH), a previously unreported complication during cataract surgery in eyes with lens subluxation.
Methods: A retrospective observational case series was conducted on five male patients who developed ICBH during phacoemulsification with intraocular lens (IOL) implantation between January 2019 and December 2024. Among 867 subluxated-lens surgeries performed during this period, the estimated incidence of ICBH was 0.
Clin Ophthalmol
September 2025
Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.
Purpose: To compare postoperative astigmatism and visual acuity (VA) outcomes in patients undergoing penetrating keratoplasty (PK) using a liquid-interface femtosecond laser (LI-fs) trephination and a conventional vacuum-trephine (VT) technique.
Methods: Our single-center, retrospective data analysis included 121 eyes (121 patients) treated between April 2014 and November 2022. Patients received PK either with a LI-fs or a VT system.