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Objective: To investigate the quality of information related to glaucoma procedures found online using 2 different assessment tools.
Design: Cross-sectional survey of 100 web sites found via Google search engine.
Methods: The terms "peripheral iridotomy" and "trabeculectomy" along with synonymous keywords were inputted into Google's search engine. The first 50 functional websites for each term were assessed by 2 independent raters using the DISCERN instrument as well as a quality assessment tool by the Journal of the American Medical Association (JAMA). Statistical analysis included an evaluation of intra-rater reproducibility and interclass correlation between the 2 scales.
Main Outcome Measures: (i) Quality of web site content based on DISCERN and JAMA scores, (ii) quality of web site based on categorization of web site (iii), intra-rater reproducibility of each scale, and (iv) interclass correlation between the 2 rating scales.
Results: Only 22% of the web sites for peripheral iridotomy and 34% of the web sites for trabeculectomy met all the criteria for JAMA's quality assessment. The mean DISCERN scores for peripheral iridotomy and trabeculectomy were 44 and 43.7, respectively, indicating poor quality. For the DISCERN scale, level of agreement between raters for each question ranged from κ = 0.550 (95% confidence interval [CI] 0.700-1.026) to κ = 0.884 (95% CI 0.751-1.017). For the JAMA 4 scale, level of agreement for each question ranged from κ = 0.874 (95% CI 0.734-1.01) to κ = 1.00.
Conclusion: Our study indicates that information found online for two common ophthalmic procedures is of variable and poor quality. Thus, patients may be receiving misinformation online and better measures need to be implemented to avoid the dissemination of low-quality health information.
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http://dx.doi.org/10.1016/j.jcjo.2021.02.010 | DOI Listing |
Zhongguo Ying Yong Sheng Li Xue Za Zhi
September 2025
PSIT-Pranveer Singh Institute of Technology (Pharmacy), Kanpur - Agra - Delhi, NH#2, Bhauti, Kanpur, Uttar Pradesh, India.
Hemocyanin is dissolved freely in hemolymph, the invertebrate blood substitute, in contrast to haemoglobin, which is encased in red blood cells. When oxygenated, this pigment gives mollusc and arthropod blood its characteristic blue or purple hue. This review article delves into the fascinating biology of hemocyanin, the copper-based oxygen-carrying protein responsible for "purple blood" in many invertebrates, contrasting its characteristics with the more familiar iron-based hemoglobin.
View Article and Find Full Text PDFJ Neural Eng
September 2025
Eindhoven University of Technology, De Rondom 70, Eindhoven, 5612 AP, NETHERLANDS.
Transcranial temporal interference stimulation (tTIS) has recently emerged as a non-invasive neuromodulation method aimed at reaching deeper brain regions than conventional techniques. However, many questions about its effects remain, requiring further experimental studies. This review consolidates the experimental literature on tTIS's effects in the human brain, clarifies existing evidence, identifies knowledge gaps, and proposes future research directions to evaluate its potential.
View Article and Find Full Text PDFLancet Infect Dis
September 2025
The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Background: Based on results from preclinical and clinical studies, a five-drug combination of isoniazid, rifapentine, pyrazinamide, ethambutol, and clofazimine was identified with treatment shortening potential for drug-susceptible tuberculosis; the Clo-Fast trial aimed to determine the efficacy and safety of this regimen. We compared 3 months of isoniazid, rifapentine, pyrazinamide, ethambutol, and clofazimine, administered with a clofazimine loading dose, to the standard 6 month regimen of isoniazid, rifampicin, pyrazinamide, and ethambutol in drug-susceptible tuberculosis.
Methods: Clo-Fast was a phase 2c open-label trial recruiting participants at six sites in five countries.
Curr HIV Res
August 2025
Department of Biotechnology, Quaid-i-Azam University, Islamabad, Pakistan.
The poor solubility and bioavailability of antiretroviral drugs complicate the manage-ment of Human Immunodeficiency virus. The efficacy of these medications is diminished due to restricted absorption in the gastrointestinal tract. Patients often exhibit a wide range of reactions attributable to fluctuations in blood drug concentrations.
View Article and Find Full Text PDFEcology
September 2025
U.S. Geological Survey, Pennsylvania Cooperative Fish and Wildlife Research Unit, The Pennsylvania State University, University Park, Pennsylvania, USA.
Invasive species are drivers of ecological change with the potential to reshape the structure and function of terrestrial and aquatic ecosystems. The invasive flathead catfish (Pylodictis olivaris) is an opportunistic predator that has established a rapidly growing population in the Susquehanna River, Pennsylvania, USA, since they were first detected in 2002. Although the predatory effects of invasive catfishes on native fish communities have been documented, the effects of invasion on riverine food webs are poorly understood.
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