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Article Abstract
Background: The present study aimed to investigate the antifungal activity of Nanoparticles (NPs) against amphotericin B-resistant strains.
Methods: Twelve resistant strains were isolated from archived clinical isolates. Antifungal activity was conducted according to Clinical and Laboratory Standards Institute's (CLSI) guidelines, document M27-A3/S4. The Scanning Electron Microscope (SEM) was used to observe the morphological changes of strains exposed to each nanoparticle.
Results: Minimum Inhibitory Concentration (MIC) of nanoparticles of all strains was in the concentration range of 0.125 to 0.5 . The synthesized Ag-NPs showed superior antifungal activity against compared to Se-NPs and Au-NPs. The scanning electron microscope images revealed the difference in the fungal morphology between the untreated and treated fungi with nanoparticles.
Conclusion: The Ag-NPs, followed by Se-NPs synthesized, revealed significant anti-fungal activity against resistance regardless of their antifungal-resistant mechanisms.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903435 | PMC |
| http://dx.doi.org/10.18502/ajmb.v13i1.4578 | DOI Listing |
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