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Equilibrium Propagation is a biologically-inspired algorithm that trains convergent recurrent neural networks with a local learning rule. This approach constitutes a major lead to allow learning-capable neuromophic systems and comes with strong theoretical guarantees. Equilibrium propagation operates in two phases, during which the network is let to evolve freely and then "nudged" toward a target; the weights of the network are then updated based solely on the states of the neurons that they connect. The weight updates of Equilibrium Propagation have been shown mathematically to approach those provided by Backpropagation Through Time (BPTT), the mainstream approach to train recurrent neural networks, when nudging is performed with infinitely small strength. In practice, however, the standard implementation of Equilibrium Propagation does not scale to visual tasks harder than MNIST. In this work, we show that a bias in the gradient estimate of equilibrium propagation, inherent in the use of finite nudging, is responsible for this phenomenon and that canceling it allows training deep convolutional neural networks. We show that this bias can be greatly reduced by using symmetric nudging (a positive nudging and a negative one). We also generalize Equilibrium Propagation to the case of cross-entropy loss (by opposition to squared error). As a result of these advances, we are able to achieve a test error of 11.7% on CIFAR-10, which approaches the one achieved by BPTT and provides a major improvement with respect to the standard Equilibrium Propagation that gives 86% test error. We also apply these techniques to train an architecture with unidirectional forward and backward connections, yielding a 13.2% test error. These results highlight equilibrium propagation as a compelling biologically-plausible approach to compute error gradients in deep neuromorphic systems.
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http://dx.doi.org/10.3389/fnins.2021.633674 | DOI Listing |
Phys Biol
August 2025
Istituto sistemi Complessi, Consiglio Nazionale delle Ricerche, Via dei Taurini 19, Roma, Roma, Lazio, 00185, ITALY.
Understanding the link between structure and function in proteins is fundamental in molecular biology and proteomics. A central question in this context is whether allostery - where the binding of a molecule at one site affects the activity of a distant site - emerges as a further manifestation of the intricate interplay between structure, function, and intrinsic dynamics. This study explores how allosteric regulation is modified when intrinsic protein dynamics operate under out-of-equilibrium conditions.
View Article and Find Full Text PDFSci Rep
August 2025
Business School, University of Shanghai for Science and Technology, Shanghai, 200093, China.
Rumor spreading has been posing a significant threat to maintain the normal social order. In this paper, we propose a ISDR rumor propagation model on scale-free networks that considers fractional-order and refutation mechanism. we acquire basic reproduction number [Formula: see text] based on the rumor equilibrium point [Formula: see text], which thoroughly characterizes the dynamics of rumor propagation.
View Article and Find Full Text PDFPhys Chem Chem Phys
August 2025
Keck Center for Science and Engineering, Graduate Program in Computational and Data Sciences, Schmid College of Science and Technology, Chapman University, Orange, CA 92866, USA.
The ongoing evolution of SARS-CoV-2 variants has underscored the need to understand not only the structural basis of antibody recognition but also the dynamic and allosteric mechanisms that could be the underlying contributors to their complex broad and escape-resistant neutralization activities. In this study, we employed a multi-scale approach integrating structural analysis, hierarchical molecular simulations, mutational scanning and network-based allosteric modeling to dissect how class 4 antibodies (represented by S2X35, 25F9, and SA55) and class 5 antibodies (represented by S2H97, WRAIR-2063 and WRAIR-2134) can modulate conformational behavior, binding energetics, allosteric interactions and immune escape patterns of the SARS-CoV-2 spike protein. Using hierarchical simulations of the antibody complexes with the spike protein and ensemble-based mutational scanning of binding interactions we showed that these antibodies through targeting conserved cryptic sites can exert allosteric effects that influence global conformational dynamics in the RBD functional regions.
View Article and Find Full Text PDFPlants (Basel)
July 2025
College of Mechanical and Electrical Engineering, Gansu Agricultural University, Lanzhou 730070, China.
To address the challenges of low recognition accuracy and substantial model complexity in crop disease identification models operating in complex field environments, this study proposed a novel hybrid model named ConvTransNet-S, which integrates Convolutional Neural Networks (CNNs) and transformers for crop disease identification tasks. Unlike existing hybrid approaches, ConvTransNet-S uniquely introduces three key innovations: First, a Local Perception Unit (LPU) and Lightweight Multi-Head Self-Attention (LMHSA) modules were introduced to synergistically enhance the extraction of fine-grained plant disease details and model global dependency relationships, respectively. Second, an Inverted Residual Feed-Forward Network (IRFFN) was employed to optimize the feature propagation path, thereby enhancing the model's robustness against interferences such as lighting variations and leaf occlusions.
View Article and Find Full Text PDFSci Adv
August 2025
Department of Physics, University of Konstanz, 78464 Konstanz, Germany.
In topology, averaging over local geometrical details reveals robust global features. These are crucial in physics for understanding quantized bulk transport and exotic boundary effects of linear wave propagation in (meta-)materials. Beyond linear Hamiltonian systems, topological physics strives to characterize open (non-Hermitian) and interacting systems.
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