Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

[Figure: see text].

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946727PMC
http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.16831DOI Listing

Publication Analysis

Top Keywords

microrna-210 mediates
4
mediates hypoxia-induced
4
hypoxia-induced repression
4
repression spontaneous
4
spontaneous transient
4
transient outward
4
outward currents
4
currents sheep
4
sheep uterine
4
uterine arteries
4

Similar Publications

Background: This study explored the interrelationships among vascular endothelial growth factor A (VEGF-A), microRNA-210 (miR-210), and EphrinA3 in the plasma of patients with coronary heart disease (CHD), and their collective influence on coronary collateral circulation (CCC) development.

Methods: We enrolled 253 patients with ≥ 90% stenosis in at least one coronary artery, stratified into good CCC (n = 99) and poor CCC (n = 154) groups according to the Rentrop grading system. Plasma concentrations of miR-210, VEGF-A, and EphrinA3 were quantified via qRT-PCR and ELISA.

View Article and Find Full Text PDF

MicroRNA-210 Mediates Hypoxic Pulmonary Hypertension in the Newborn Lamb.

Hypertension

June 2025

Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences (X.-Q.H., R.S., C.D., S.T.-B., A.A., S.F.H., L.Z., A.B.B.), Loma Linda University School of Medicine, CA.

Background: Pulmonary hypertension of the newborn is a life-threatening disorder characterized by elevated pulmonary vascular resistance due to maladaptation of the pulmonary circulation after birth. The pathogenesis and mechanisms underlying pulmonary hypertension of the newborn remain unclear, hindering the development of effective treatment. We hypothesize that perinatal chronic hypoxia upregulates microRNA-210, which is essential for suppression of pulmonary arterial spontaneous transient outward currents (STOCs), resulting in pulmonary hypertension of the newborn.

View Article and Find Full Text PDF

MicroRNA-210 mediates hypoxia-induced pulmonary hypertension by targeting mitochondrial bioenergetics and mtROS flux.

Acta Physiol (Oxf)

September 2024

Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, California, USA.

Aim: Chronic hypoxia is a common cause of pulmonary hypertension (PH). We test the hypothesis that microRNA-210 (miR-210) mediates hypoxia-induced PH by targeting mitochondrial metabolism and increasing reactive oxygen species (mtROS) production in the lungs.

Methods: Adult wildtype (WT) or miR-210 knockout (KO) mice were exposed to hypoxia (10.

View Article and Find Full Text PDF

Morinda officinalis polysaccharide (MOP) is the bioactive ingredient extracted from the root of Morinda officinalis, and Morinda officinalis is applied to treat osteoporosis (OP). The purpose of this study was to determine the role of MOP on human bone marrow mesenchymal stem cells (hBMSCs) and the underlying mechanism. HBMSCs were isolated from bone marrow samples of patients with OP and treated with MOP.

View Article and Find Full Text PDF

Diallyl trisulfide (DATS) protects cardiac cells against advanced glycation end-product-induced apoptosis by enhancing FoxO3A-dependent upregulation of miRNA-210.

J Nutr Biochem

March 2024

Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan ROC; Program for Biotechnology Industry, China Medical University, Taichung, Taiwan ROC. Electronic address:

Diabetic cardiomyopathy is a common complication of diabetes, resulting in cardiac hypertrophy and heart failure associated with excessive reactive oxygen species and mitochondria-mediated apoptosis generation. Mitogen-activated protein kinase-c-Jun N-terminal kinase (MAPK-JNK), regulated by microRNA (miR)-210, affects mitochondrial function and is activated by advanced glycation end-products (AGE) in cardiac cells. Diallyl trisulfide (DATS), an antioxidant in garlic oil, inhibits stress-induced cardiac apoptosis.

View Article and Find Full Text PDF