98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881206 | PMC |
http://dx.doi.org/10.1038/s41467-021-21182-8 | DOI Listing |
Nat Rev Nephrol
September 2025
Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
The global shortage of suitable donor kidneys is the primary challenge in kidney transplantation, and it is exacerbated by ageing donors with increased numbers of health issues. Improving organ assessment, preservation and conditioning could enhance organ utilization and patient outcomes. Hypothermic machine perfusion (HMP) is associated with better results than static cold storage by reducing delayed graft function and improving short-term graft survival, especially in kidneys recovered from marginal-quality donors.
View Article and Find Full Text PDFPerfusion
September 2025
Department of Surgery, Columbia University, New York, NY, USA.
Static cold storage (SCS) on ice has remained the gold standard preservation method for heart transplantation, and prolonged cold ischemia outside the typical 4-6 hour window is associated with an increased risk of primary graft dysfunction - a consequence attributed to ischemic damage and reperfusion injury. This, unfortunately limits the travel radius for donor heart procurement, a key factor that contributes to the overall shortage of donor organs. Recent research and clinical data have illustrated the validity of other preservation systems in preserving cardiac allografts, and many of these devices have shown promise in potentially prolonging the tolerated ischemic time beyond the accepted standard.
View Article and Find Full Text PDFJ Cardiovasc Transl Res
September 2025
Department of Cardiac Surgery, University Hospital Halle (Saale), University of Halle, Ernst-Grube-Straße 40, 06120, Halle (Saale), Germany.
We compared the effects of ex-vivo machine perfusion (EVMP) of hearts donated after circulatory death (DCD) with the single-shot solutions HTK-N and Del Nido cardioplegia (DNC) on left-ventricular (LV) contractility and myocardial microcirculation. In a DCD pig model, hearts were maintained by EVMP with hypothermic, oxygenated HTK-N (DCD-HTK-N; N = 8) or DNC (DCD-DNC; N = 8) followed by reperfusion with blood, including assessment of contractility and microcirculation with Laser-Doppler-Flow (LDF). We performed transcriptomics using microarrays.
View Article and Find Full Text PDFBiomed Eng Lett
September 2025
Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control, School of Mechanical Engineering, Tianjin University of Technology, Tianjin, 300384 China.
Hypothermia, a component of the "lethal triad," commonly complicates the condition of critically injured trauma patients, thereby substantially elevating the risk of mortality. This study develop and evaluate a dynamic warning system based on non-invasive features, aimed at predicting the likelihood of hypothermia occurring in trauma patients within the next hour. 462 patients from the eICU database were selected on the basis of meeting the inclusion criteria, and 19 non-invasive and 17 invasive features were extracted.
View Article and Find Full Text PDFMedicine (Baltimore)
August 2025
Operating Room, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
This study aimed to develop and evaluate a machine learning based risk prediction model for intraoperative hypothermia (IOH) in patients undergoing thoracoscopic lung cancer surgery and interpret the model using the SHapley Additive exPlanations (SHAP) method to assess the contribution of specific features to the prediction results. A retrospective analysis was conducted on 717 patients who underwent thoracoscopic lung cancer surgery at a tertiary hospital in Wuhan from January 2022 to December 2023. The dataset was randomly divided into a training set (n = 502) and a testing set (n = 215) at a 7:3 ratio.
View Article and Find Full Text PDF