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Background: Misconceptions about ADHD stigmatize affected people, reduce credibility of providers, and prevent/delay treatment. To challenge misconceptions, we curated findings with strong evidence base.
Methods: We reviewed studies with more than 2000 participants or meta-analyses from five or more studies or 2000 or more participants. We excluded meta-analyses that did not assess publication bias, except for meta-analyses of prevalence. For network meta-analyses we required comparison adjusted funnel plots. We excluded treatment studies with waiting-list or treatment as usual controls. From this literature, we extracted evidence-based assertions about the disorder.
Results: We generated 208 empirically supported statements about ADHD. The status of the included statements as empirically supported is approved by 80 authors from 27 countries and 6 continents. The contents of the manuscript are endorsed by 366 people who have read this document and agree with its contents.
Conclusions: Many findings in ADHD are supported by meta-analysis. These allow for firm statements about the nature, course, outcome causes, and treatments for disorders that are useful for reducing misconceptions and stigma.
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http://dx.doi.org/10.1016/j.neubiorev.2021.01.022 | DOI Listing |
J Sci Food Agric
September 2025
Microbial Biotechnology Research Group, School of Life Sciences and Technology, Institut Teknologi Bandung, Bandung, Indonesia.
Background: Secondary fermentation can reduce variability in cocoa bean quality caused by the spontaneous, uncontrolled nature of primary fermentation. However, its optimization remains unexplored. This study evaluated the improvement of secondary fermentation through the combined use of Citrus limon peel and inoculation with Candida tropicalis H1Y4-1 as a starter.
View Article and Find Full Text PDFPediatr Transplant
November 2025
Division of Urology, University of Toronto, Toronto, Canada.
Introduction: Differentiating acute tubular necrosis (ATN) from rejection in pediatric kidney transplant (KT) recipients remains challenging and necessitates invasive biopsy. Doppler ultrasound-derived resistive index (RI) is a noninvasive modality to assess graft status, but its diagnostic utility in children is unclear. This study evaluates RI's ability to distinguish ATN and rejection in KT.
View Article and Find Full Text PDFBiol Methods Protoc
June 2025
LARN Laboratory (LARN-NARILIS/NISM), University of Namur, Namur, B-5000, Belgium.
The precise determination of viral titers in virological studies is a critical step to assess the infectious viral concentration of a sample. Although conventional titration methods, such as endpoint dilution or plaque forming units are the gold standards, their widespread use for screening experiments remains limited due to the time-consuming aspect and resource-intensive requirements. This study introduces a rapid and user-friendly high-throughput screening assay for evaluating viral titers.
View Article and Find Full Text PDFFront Public Health
September 2025
Department of Economics and Management, Jiangsu College of Administration, Nanjing, China.
This study utilizes data from the China Cancer Registry Annual Report and the "Qichacha" database to construct a time-region regression model based on panel data, aiming to explore the impact of polluting enterprises on regional cancer incidence rates between 2000 and 2008. The empirical analysis reveals that polluting enterprises significantly increase cancer incidence rates among both male and female populations, with a particularly marked effect on lung cancer. Heterogeneity analysis shows that the effect is most pronounced in the eastern and coastal regions, followed by the central and northeastern areas, with minimal impact in the western and inland regions.
View Article and Find Full Text PDFClin Pharmacol
September 2025
Department of Biology, College of Science Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Cancer remains the second leading cause of death worldwide, highlighting the urgent need for novel therapeutic approaches. Fungi are a rich source of bioactive metabolites, some of which exhibit potent anticancer properties. This scoping review evaluates the current research on fungal metabolites with anticancer potential, focusing on species native to Saudi Arabia's unique ecosystem.
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