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Canonical correlation analysis (CCA) is a common method used to estimate the associations between two different sets of variables by maximizing the Pearson correlation between linear combinations of the two sets of variables. We propose a version of CCA for transelliptical distributions with an elliptical copula using pairwise Kendall's tau to estimate a latent scatter matrix. Because Kendall's tau relies only on the ranks of the data this method does not make any assumptions about the marginal distributions of the variables, and is valid when moments do not exist. We establish consistency and asymptotic normality for canonical directions and correlations estimated using Kendall's tau. Simulations indicate that this estimator outperforms standard CCA for data generated from heavy tailed elliptical distributions. Our method also identifies more meaningful relationships when the marginal distributions are skewed. We also propose a method for testing for non-zero canonical correlations using bootstrap methods. This testing procedure does not require any assumptions on the joint distribution of the variables and works for all elliptical copulas. This is in contrast to permutation tests which are only valid when data are generated from a distribution with a Gaussian copula. This method's practical utility is shown in an analysis of the association between radial diffusivity in white matter tracts and cognitive tests scores for six-year-old children from the Early Brain Development Study at UNC-Chapel Hill. An R package implementing this method is available at github.com/blangworthy/transCCA.
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http://dx.doi.org/10.1016/j.jmva.2020.104715 | DOI Listing |
BMC Pediatr
September 2025
Department of Neonatology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, China.
Background: Red blood cell (RBC) transfusion is a common intervention for anemia in preterm infants; however, its association with bronchopulmonary dysplasia (BPD) remains debated. While biological mechanisms suggest potential harm, the clinical impact of transfusion frequency on BPD incidence and severity remains unclear.
Objective: To investigate whether RBC transfusion frequency is independently associated with the risk and severity of BPD in preterm infants born before 32 weeks of gestation.
J Neurol
September 2025
Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Background: The "Systematic Screening of Handwriting Difficulties in Parkinson's Disease" (SOS) test is the only tool specifically designed to evaluate handwriting in people with Parkinson's Disease (pwPD). It is language specific.
Objective: To assess the construct validity, intrarater and interrater reliability of the Italian version of the SOS test.
BMJ Public Health
August 2025
School of Population Health, The University of Auckland, Auckland, New Zealand.
Introduction: Illicit tobacco poses a significant challenge to public health efforts. New Zealand (NZ) stands out for its stringent tobacco control policies, but there are concerns that the size of the illicit market could grow. Estimating the extent of the illicit tobacco trade in NZ remains challenging due to the diverse methodologies used by various stakeholders over different years.
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August 2025
King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
With the recent popularity of neural networks comes the need for efficient serving of inference workloads. A neural network inference workload can be represented as a computational graph with nodes as operators transforming multidimensional tensors. The tensors can be transposed and/or tiled in a combinatorially large number of ways, some configurations leading to accelerated inference.
View Article and Find Full Text PDFCureus
September 2025
Neurosurgery, Queen Elizabeth University Hospital, Glasgow, GBR.
Background Emergency neurosurgical referrals are a leading driver of on-call workload and unplanned admissions. Tracking their volume and case-mix supports safe staffing, imaging capacity, and bed planning across regional networks. The study included all emergency referrals made to the department between 2020 and 2022.
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