Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Six new triterpenes, uncarinic acids KP (), along with 24 known analogues, were isolated as minor constituents of an aqueous decoction of the hook-bearing stems of (Gou-teng). By comprehensive spectroscopic data analysis, their structures were elucidated as derivatives of olean-12-en-28-oic acid and urs-12-en-28-oic acid with different oxidized forms at C-3, C-6, and/or C-23, respectively. Cell-based preliminary bioassay showed that the ()-/()-coumaroyloxy and ()-/()-feruloyloxy units at C-27 of olean-12-en-28-oic acid and urs-12-en-28-oic acid played roles in their bioactivities.[Formula: see text].
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/10286020.2020.1870961 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A computational effort to untangling anti-SARS-CoV-2 effects of oleanolic acid analogues.
Pak J Pharm Sci
July 2025
Department of Cellular and Molecular Biology, Faculty of Life and Natural Science, University of El Oued, Algeria.
Considering the current global pandemic and the urgent need to introduce novel drug candidates against severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), we reported at least four antipyretic recipes of Kurdish ethnomedicine which can be translated to functional antiviral formulations in orthodox medicine (Mohammed et al., 2020). Our current demanding computational work places much emphasis upon the implications of oleanolic acid and its analogues as a cluster of binder candidates of the main protease (M) of SARS-CoV-2 which having a pivotal role in the pathogenesis of coronavirus disease 2019 (COVID-19).
View Article and Find Full Text PDFBis-Iridoid Glycosides and Triterpenoids from and Their Potential as Inhibitors of ACC1 and ACL.
Molecules
December 2024
Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, School of Pharmaceutical Sciences, Taizhou University, Taizhou 318000, China.
A comprehensive phytochemical investigation of the twigs/leaves and flower buds of , a rare deciduous shrub native to China, led to the isolation of 39 structurally diverse compounds. These compounds include 11 iridoid glycosides (- and -), 20 triterpenoids (, , and -), and 8 phenylpropanoids (-). Among these, amabiliosides A () and B () represent previously undescribed bis-iridoid glycosides, while amabiliosides C () and D () feature a unique bis-iridoid-monoterpenoid indole alkaloid scaffold with a tetrahydro--carboline-5-carboxylic acid moiety.
View Article and Find Full Text PDFHederagenin Glycoside Isolated from the Pericarps of Fruits Induces Apoptotic Cell Death in Breast Cancer Cells.
Anticancer Res
January 2025
Faculty of Pharmacy, Iryo Sosei University, Iwaki, Japan.
Background/aim: Hederagenin (3β,4α-3,23-dihydroxyolean-12-en-28-oic acid) is a natural pentacyclic triterpene that is present in various medicinal plants and exhibits pharmacological activities against various diseases, including cancer. The aim of the study was to investigate the effect of Aq3639 (3β-[(O-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl)oxy]olean-12-en-28-oic acid), a hederagenin glycoside comprising hederagenin and a disaccharide of L-rhamnose and L-arabinose, on breast cancer cells.
Materials And Methods: Aq3639 was isolated from the pericarps of Akebia quinata fruits, and its effects on cells from the human breast cell line MCF-7 were examined.
Phytochemical and antimicrobial evaluation of Triana (Melastomataceae).
Nat Prod Res
October 2024
Exact and Technological Sciences Campus, State University of Goiás, Anápolis, GO, Brazil.
Four novel triterpenoid saponins, 1,3,23-trihydroxy-olean-12-en-28-oic acid 28---glycopyranoside ester (), 1,3,23-trihydroxy-urs-12-en-28-oic acid 28---glycopyranoside ester (), 3---galloyl-1,23-dihydroxy-olean-12-en-28-oic acid 28---glycopyranoside ester () and 3---galloyl-1,23-dihydroxy-urs-12-en-28-oic acid 28---glycopyranoside ester () and two new pentacyclic triterpenoids, 3-----coumaroyl-1-hydroxy-urs-12-en-28-oic acid () and 3-----coumaroyl-1-hydroxy-urs-12-en-28-oic acid (), together with six known compounds were isolated from the ethanolic extracts of leaves and stem bark. Their structures were established by HR-MS, 1D and 2D NMR and comparison with literature data. Additionally, the antimicrobial activity of the leaves and stem bark extracts and fractions was evaluated using the micro broth dilution technique.
View Article and Find Full Text PDFPredicting structure-targeted food bioactive compounds for middle-aged and elderly Asians with myocardial infarction: insights from genetic variations and bioinformatics-integrated deep learning analysis.
Food Funct
September 2024
Department of Bioconvergence, Hoseo University, Asan 31499, Korea.
Myocardial infarction (MI) is a significant global health issue. Despite the advances in genome-wide association studies, a complete genetic and molecular understanding of MI is elusive and needs to be fully explored. This study aimed to elucidate the genetic framework of MI and explore the potential health benefits of natural compounds (NCs).
View Article and Find Full Text PDF