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Autism spectrum disorder (ASD) may be accompanied by aggressive behavior and is associated with sensory processing difficulties. The present study aims to investigate the direct association between sensory processing and aggressive behavior in adults with ASD. A total of 101 Dutch adult participants with ASD, treated in outpatient or inpatient facilities, completed the Adult/Adolescent Sensory Profile (AASP), the Reactive-Proactive Aggression Questionnaire (RPQ), and the Aggression Questionnaire-Short Form (AQ-SF). Results revealed that sensory processing difficulties are associated with more aggressive behavior (f2=0.25), more proactive (f2=0.19) and reactive aggression (f2=0.27), more physical (f2=0.08) and verbal aggression (f2=0.13), and more anger (f2=0.20) and hostility (f2=0.12). Evidence was found for an interaction of the neurological threshold and behavioral response on total aggression and hostility. Participants with higher scores in comparison to the norm group in sensory sensitivity had the highest risk of aggressive behavior. In conclusion, clinical practice may benefit from applying detailed diagnostics on sensory processing difficulties when treating aggressive behavior in adults with ASD.
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http://dx.doi.org/10.3390/brainsci11010095 | DOI Listing |
Accid Anal Prev
September 2025
Department of Traffic Engineering and Key Laboratory of Road and Traffic Engineering Ministry of Education, Tongji University, Shanghai 201804, China. Electronic address:
In future traffic environments dominated by highly autonomous vehicles (AVs), pedestrians may face challenges in accurately interpreting AV behavior, thereby potentially increasing the risk of pedestrian-AV interactions. External human-machine interfaces (eHMIs) have been proposed to facilitate communication between AVs and pedestrians; however, comprehensive evaluations using objective data from real-world interactions are limited. This study developed a systematic evaluation framework grounded in the ISO 9241-11 standard, integrating four key indicators: decision accuracy, comprehensibility, decision efficiency, and perceived safety.
View Article and Find Full Text PDFBiochem Soc Trans
September 2025
Department of Biochemistry, McGill University, Montréal, QC, Canada.
The MET receptor tyrosine kinase is a pivotal regulator of cellular survival, motility, and proliferation. Mutations leading to skipping of exon 14 (METΔex14) within the juxtamembrane domain of MET impair receptor degradation and prolong oncogenic signaling, contributing significantly to tumor progression across multiple cancer types. METΔex14 mutations are associated with aggressive clinical behavior, therapeutic resistance, and poor outcomes.
View Article and Find Full Text PDFPLoS One
September 2025
School of Psychology and Neuroscience, University of St Andrews, St Andrews, Fife, Scotland.
Many animal species live in multi-level societies regulated by complex patterns of dominance. Avoiding competition with dominant group-mates for resources such as food and mates is an important skill for subordinate individuals in these societies, if they wish to evade harassment and aggression. Chimpanzees (Pan troglodytes) are an example of such a species.
View Article and Find Full Text PDFJ Neurooncol
September 2025
Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Purpose: NOTCH3 is increasingly implicated for its oncogenic role in many malignancies, including meningiomas. While prior work has linked NOTCH3 expression to higher-grade meningiomas and treatment resistance, the metabolic phenotype of NOTCH3 activation remains unexplored in meningioma.
Methods: We performed single-cell RNA sequencing on NOTCH3 + human meningioma cell lines.
Urologie
September 2025
Klinik für Urologie, Medizinisches Forschungszentrum, Urologisches Forschungslabor, Translationale UroOnkologie, Medizinische Fakultät und Universitätsklinikum Düsseldorf, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Deutschland.
Type II testicular germ cell tumors (GCT) are the most common malignant disease in young men, with a steadily increasing incidence. They originate from germ cell neoplasia in situ and are classified into seminomas (SE) and nonseminomas (NS). The NS subtype embryonal carcinoma (EC) exhibits stem cell-like characteristics and, thus, has the potential to differentiate into teratomas (TE) or extraembryonic tissues, such as yolk-sac tumors (YST) and choriocarcinomas (CC).
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