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Background: Patient surges beyond hospital capacity during the initial phase of the COVID-19 pandemic emphasized a need for clinical laboratories to prepare test processes to support future patient care. The objective of this study was to determine if current instrumentation in local hospital laboratories can accommodate the anticipated workload from COVID-19 infected patients in hospitals and a proposed field hospital in addition to testing for non-infected patients.
Methods: Simulation models predicted instrument throughput and turn-around-time for chemistry, ion-selective-electrode, and immunoassay tests using vendor-developed software with different workload scenarios. The expanded workload included tests from anticipated COVID patients in 2 local hospitals and a proposed field hospital with a COVID-specific test menu in addition to the pre-pandemic workload.
Results: Instrumentation throughput and turn-around time at each site was predicted. With additional COVID-patient beds in each hospital, the maximum throughput was approached with no impact on turnaround time. Addition of the field hospital workload led to significantly increased test turnaround times at each site.
Conclusions: Simulation models depicted the analytic capacity and turn-around times for laboratory tests at each site and identified the laboratory best suited for field hospital laboratory support during the pandemic.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798967 | PMC |
http://dx.doi.org/10.1093/jalm/jfaa231 | DOI Listing |
Stem Cell Rev Rep
September 2025
Department of Medical Genetics and Prenatal Diagnostics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
The emergence of organoid models has significantly bridged the gap between traditional cell cultures/animal models and authentic human disease states, particularly for genetic disorders, where their inherent genetic fidelity enables more biologically relevant research directions and enhances translational validity. This review systematically analyzes established organoid models of genetic diseases across organs (e.g.
View Article and Find Full Text PDFAnal Bioanal Chem
September 2025
GuangDong Engineering Technology Research Center of Antibody Drug and Immunoassay, Department of Biological Sciences and Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China.
Illicit drug abuse poses a significant global threat to public health and social security, highlighting the urgent need for rapid, sensitive, and versatile detection technologies. To address the limitations of traditional chromatographic techniques-such as high costs and slow response times-and the drawbacks of conventional immunochromatographic sensors (ICS), including low sensitivity and non-intuitive signal outputs, a fluorescence-quenching ICS (FQICS) was developed. This sensor leverages fluorescence resonance energy transfer (FRET) between aggregation-induced emission fluorescent microspheres (AIEFMs) and gold nanoparticles (AuNPs).
View Article and Find Full Text PDFNat Rev Urol
September 2025
Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Low-grade non-muscle invasive bladder cancer is a specific category of bladder cancer with a favourable prognosis; however, its management presents several challenges. The risk of stage progression is very low, but approximately half of patients will experience recurrence within the first 5 years after diagnosis. This high propensity for recurrence, coupled with the threat of progression, mandates ongoing surveillance.
View Article and Find Full Text PDFJ Pediatr Urol
August 2025
School of Medicine and Pharmacy, University of Poitiers, 6 Rue de la Milétrie, TSA 51115, 86073, Poitiers Cedex, France; Clinical Investigation Center, INSERM, 2 Rue de la Milétrie 1402, 86021, Poitiers, France; University of Poitiers, CNRS UMR7267, Ecologie & Biologie des Interactions, 86000, Poi
Purpose: The high frequency of urinary disorders and their complications among school-aged children is common but few studies have investigated their predictors such as poor urinary hygiene habits, inappropriate use of school toilets, and deteriorated school toilets conditions. The question is whether individual factors (behaviors) conditioned by environmental factors (toilet conditions) play a role in functional urinary disorders.
Materials And Methods: We performed an electronic cross-sectional observational study from October 1, 2023, to March 31, 2024, in the department of Vienne (France), among children's parents.
Magn Reson Med Sci
September 2025
Department of Radiology and Neuroradiology, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Schleswig-Holstein, Germany.
Purpose: The ability to accurately detect and characterize intramammary micro- and macrocalcifications without ionized radiation has significant clinical implications for early breast cancer assessment. The aim of this prospective study was to investigate the feasibility of detecting intramammary calcifications using 3D multi-echo gradient echo (ME-GRE) magnitude and true susceptibility-weighted images (tSWI) compared to digital mammography (DM) in patients with different breast sizes and densities of breast parenchyma at 1.5T.
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