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There is a critical need for new efficient solutions to purify and disinfect water from source to point-of-use, especially for the water contaminated by pathogenic microbes. Traditional disinfection technologies are chemically intensive and limited, either by biofouling or by the irreversible consumption of disinfectants. Herein, we present a scalable methodology to create biocidal and rechargeable nanofibrous membranes (BNF membranes) by combining -halamine antimicrobial agent with electrospun nanofibers. Our method allows intrinsically rechargeable -halamine moieties to covalently incorporate into nanofibers with high biocidal activity and durability. The resulting BNF membranes exhibit integrated properties of high porosity, large surface area, robust mechanical strength, super hydrophilicity, rechargeable chlorination capability (>3000 ppm), and high bactericidal efficacy (99.9999% contact-killing), which enabled the BNF membranes effectively disinfect bacteria-contained water by direct filtration, with promising high durability and fluxes (10000 L m h). The successful synthesis of BNF membranes also provides a versatile platform for exploring the antimicrobial -halamine materials in a self-supporting, structurally adaptive, and nanofibrous form.
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http://dx.doi.org/10.1021/acsbiomaterials.7b00111 | DOI Listing |
Environ Sci Technol
July 2025
Environmental Chemistry Department, IDAEA - CSIC, C/Jordi Girona, 18-26, Barcelona 08034, Spain.
Three-dimensional (3D) cell cultures offer more physiologically relevant models than conventional cell monolayers (2D) for mimicking in vivo tissue architecture. Despite their advantages, the use of 3D fish cell models in toxicological studies remains limited. This study aims to characterize the lipidomic and gene expression profiles of zebrafish liver (ZFL) spheroids and evaluate their metabolic and functional differences compared to those of conventional monolayer cultures.
View Article and Find Full Text PDFTrends Pharmacol Sci
July 2025
Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.
Mitochondrial pyruvate carrier (MPC) inhibitors have shown promise as therapeutics for treating several chronic diseases. However, the structure of MPC and the molecular mechanisms by which it interacts with inhibitors have remained unclear, impeding rational drug design. Multiple groups have now independently resolved the structure of the MPC heterodimer.
View Article and Find Full Text PDFViruses
April 2025
Laboratory of Biology and Biotechnology of Bacteriophages, Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdansk, Poland.
The presented in silico and phylogenetic analysis of putative endolysins potentially produced by phages infecting uropathogenic (UPEC) demonstrates their remarkable diversity. These proteins exhibit significant variations in sequence length, molecular weight, isoelectric point, and stability, as well as diverse functional domains determining their enzymatic activity, including lysin, lysozyme, hydrolase, amidase, and peptidase functions. Due to their predicted lytic properties, endolysins hold great promise in combating UPEC bacteria, including those within biofilms, which are often highly resistant to conventional treatments.
View Article and Find Full Text PDFNature
December 2024
Department of Chemistry, Washington University, St Louis, MO, USA.
J Drug Target
June 2024
Department of Radiotherapy, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, China.
Radio-photothermal therapy is an effective modality for cancer treatment. To overcome the radio-resistance in the hypoxic microenvironment and improve the sensitivity of radiotherapy, metal nanoparticles, and radio-photothermal therapy are widely used in the research of improving the curative effect and reducing the side effects of radiotherapy. Here, we developed red blood membrane camouflaging bismuth nanoflowers (RBCM-BNF) with outstanding physiological stability and biodegradability for lung tumours.
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