Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
In the regenerative medicine field, allogenic transplantation of regenerated tissues has been promoted because autologous transplantation setting is costly and time-consuming to prepare and therefore unsuitable for emergent treatment. To avoid a T cell-mediated immune rejection in the allogenic transplantation setting, induced pluripotent stem cells (iPSCs) derived from different HLA haplotype-homozygous (HLA-homo) donors have been prepared to be used as source of regenerated tissues. However, there still remain immunological issues, even when HLA-homo iPSCs are used. One issue is the immune response against minor histocompatibility antigens expressed on the regenerated tissues, and the other is the immune rejection mediated by NK cells. In this article, we introduce our research on NK cell reactivity against the regenerated tissues in the HLA homo-to-hetero transplantation setting. We further introduce several approaches taken by other groups that address the NK-mediated immune rejection issue.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788987 | PMC |
| http://dx.doi.org/10.1186/s41232-020-00150-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Recent advances in intelligent oxygen delivery systems for tissue regeneration.
Adv Drug Deliv Rev
September 2025
State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China; Department of Pharmacy, The Air Force Hospital of Eastern Theater Command, Nanjing 210002, China; Jiangsu Provincial Key Laboratory of Nano Technology, Medical School, Nanjing University,
Oxygen plays a critical regulatory role in tissue repair and regeneration. However, in the microenvironment of tissues with vascular damage, hypoxia is commonly present. This not only suppresses cell proliferation and differentiation but also delays angiogenesis and extracellular matrix reconstruction, ultimately hindering the tissue regeneration process.
View Article and Find Full Text PDFEffectiveness of Platelet-Rich Fibrin or Platelet-Rich Plasma in Mandibular Fracture Management: A Systematic Review and Meta-Analysis.
J Stomatol Oral Maxillofac Surg
September 2025
Senior Consultant (Maxillofacial Head and neck Surgery), Dental and Maxillofacial Unit, Bahrain defence force Royal Medical Services, Bahrain.
This systematic review and meta-analysis aimed to critically evaluate and synthesize the available evidence on the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in the management of mandibular and non-mandibular maxillofacial fractures. A comprehensive search of electronic databases was conducted up to February 2025 based on predefined inclusion criteria. The risk of bias in randomized controlled trials was assessed using the Cochrane Risk of Bias (ROB) tool, while the Newcastle-Ottawa Scale was applied to observational studies.
View Article and Find Full Text PDFCircTTC3 regulates the osteogenic differentiation of adipose-derived mesenchymal stem cells via miR-205/Smad3 axis.
Exp Cell Res
September 2025
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu City 610041, China. Electronic address:
Adipose-derived mesenchymal stem cells (ADSCs) hold great promise for bone tissue repair and regeneration. Circular RNAs (circRNAs) play a crucial role in regulating the osteogenic differentiation and bone remodeling of ADSCs; however, the underlying molecular mechanisms remain unclear. In this study, we conducted whole transcriptome sequencing (WTS) on ADSCs and constructed a competing endogenous RNA (ceRNA) regulatory network to identify the circTTC3/miR-205/mothers against decapentaplegic homolog 3 (Smad3) signaling axis.
View Article and Find Full Text PDFAdvances in hemocytes regeneration of aquatic invertebrates: Mechanisms and implications.
Dev Comp Immunol
September 2025
State Key Laboratory of Agricultural Products Safety, Ningbo University, Ningbo, Zhejiang 315211, China; Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao Marine Science and Technology center, Qingdao, Shandong 266237, China. Electronic address:
Hematopoiesis is the process responsible for the generation of blood cells in both the circulation and tissues. It plays a crucial role in maintaining homeostasis and defending against infections in animals. Although hematopoiesis is a common feature among animals with a circulatory system, the specific mechanisms involved in hematopoietic events vary significantly among invertebrates.
View Article and Find Full Text PDFINVESTIGATIONAL AGENTS FOR ISCHAEMIC CARDIOMYOPATHY TREATMENT: PRECLINICAL AND EARLY PHASE INSIGHTS.
Expert Opin Investig Drugs
September 2025
Heart Failure Clinic, Division of Cardiology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, Italy.
Introduction: Ischemic heart disease (IHD) constitutes the most prevalent form of cardiac disease in the general population. Although current therapeutic interventions have significantly improved both quality of life and survival rates, no available treatment can reverse the loss of cardiomyocytes resulting from ischemic injury. Existing therapies are limited to attenuating myocardial damage, reducing its extent, and mitigating its clinical consequences.
View Article and Find Full Text PDF