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The advantages of a treatment modality that combines two or more therapeutic agents in cancer therapy encourages the study of hybrid functional compounds for pharmacological applications. In light of this, we reviewed recent works on hybrid molecules based on bile acids. Due to their biological properties, as well as their different chemical/biochemical reactive moieties, bile acids can be considered very interesting starting molecules for conjugation with natural or synthetic bioactive molecules.
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http://dx.doi.org/10.3390/molecules26010025 | DOI Listing |
J Med Case Rep
September 2025
Department of Anesthesiology, LMU University Hospital Munich LMU, Marchioninistrasse 15, 81377, Munich, Germany.
Background: The treatment of critically ill patients in intensive care units is becoming increasingly complex. For example, organ transplants are regularly carried out, the recipients are seriously ill, and the postoperative course can be complicated. This is why organ replacement and hemadsorption procedures are becoming increasingly important.
View Article and Find Full Text PDFEMBO J
September 2025
School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.
Insulin resistance is a heritable risk factor for many chronic diseases; however, the genetic drivers remain elusive. In seeking these, we performed genetic mapping of insulin sensitivity in 670 chow-fed Diversity Outbred in Australia (DOz) mice and identified a genome-wide significant locus (QTL) on chromosome 8 encompassing 17 defensin genes. By taking a systems genetics approach, we identified alpha-defensin 26 (Defa26) as the causal gene in this region.
View Article and Find Full Text PDFRes Vet Sci
September 2025
Interdisciplinary Laboratory of Clinical Pathology, Interlab-UMU, Campus of Excellence Mare Nostrum, University of Murcia, 30100 Murcia, Spain. Electronic address:
Recent years have seen advances in clinical biochemistry of domestic animals which have highlighted comparative differences between species and have also identified fundamental aspects of the biochemical mechanisms in physiological conditions and disease, that have implications across species, including human, health and welfare. From investigations in diverse species using biochemical, immunological, proteomic and metabolomic approaches a series of species particularities and unexpected results for some biomarkers have been made. These observations cover (1) the differences between species in the acute phase protein (APP) response to infection and inflammation; (2) the non-hepatic synthesis and release in the mammary gland, adipose tissue and intestine of APP (3) the response of haptoglobin (HP) as a biomarker for stress; (4) observations in non-mammalian species related to hemopexin and HP; (5) the response of bile acids in milk to mastitis; (6) barley serine protease inhibitors being identified in bovine faeces; (7) alkaline phosphatase being present in bovine nasal secretion; (8) saliva findings with analytes such as adenine deaminase showing different activity between saliva and serum and a detergent-like surfactant protein, latherin being found in equine saliva and sweat and (9) serum enzymes and selective muscle protein reaction of Atlantic salmon as an example of the differences in biochemistry between terrestrial and aquatic species.
View Article and Find Full Text PDFMol Pharm
September 2025
Pharmaceutical Analytical & Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Phytosterols are a class of natural steroids found in various plants. Commercially available phytosterols (PS) are primarily extracted from the deodorized distillate of soybean oil and consist predominantly of β-sitosterol with smaller amounts of stigmasterol and campesterol. Numerous studies have consistently demonstrated the significant lipid-lowering activity of PS.
View Article and Find Full Text PDFFood Res Int
November 2025
College of Public Health, Zhengzhou University, Zhengzhou, China; Food Laboratory of Zhongyuan, Luohe, Henan, China. Electronic address:
Cholesterol homeostasis dysregulation is a primary risk factor for atherosclerosis (AS) development. Fisetin, a flavonoid compound, has shown promise in regulating cholesterol homeostasis by enhancing transintestinal cholesterol excretion (TICE). This study aimed to investigate the regulatory effects and underlying mechanisms of fisetin in AS.
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