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Article Abstract
A dual-effective (photothermal and immune) therapy employing gold nanorods (AuNRs) with a drug (two macrophage migration inhibitory factor (MIF) inhibitors) sustained release hydrogel was designed in this paper. The subsequent cellular and animal studies demonstrated that the proposed therapy can not only inhibit the proliferation, migration, and recurrence of cancer cells, but also improve the immune function (increase the infiltration of CD8 killer T cells in tumors) without the traditional multiple injections of expensive immune drugs.
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| http://dx.doi.org/10.1039/d0bm01974g | DOI Listing |
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A multi-effective and long-acting immunotherapy through one single hydrogel based injection.
Biomater Sci
February 2021
The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330088, China.
A dual-effective (photothermal and immune) therapy employing gold nanorods (AuNRs) with a drug (two macrophage migration inhibitory factor (MIF) inhibitors) sustained release hydrogel was designed in this paper. The subsequent cellular and animal studies demonstrated that the proposed therapy can not only inhibit the proliferation, migration, and recurrence of cancer cells, but also improve the immune function (increase the infiltration of CD8 killer T cells in tumors) without the traditional multiple injections of expensive immune drugs.
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