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Article Abstract
A new diketopiperazine, cyclo-(-8-acetoxyl-Pro--Leu) (), together with eight known compounds (-) including three enterotoxins (-), four diketopiperazines (-) and maltol (), were isolated from the mangrove derived-soil sp. SCSIO 41400. The planar structures of all compounds were determined from analysis of NMR spectra, MS, optical rotation and comparing with literature data. The absolute configuration of compound was assigned by electronic circular dichroism (ECD). The isolated compounds (-) were tested for their acetyl cholinesterase (AChE) and pancreatic lipase (PL) enzyme inhibitory activities. Among them, the new diketopiperazine () displayed preferable PL enzyme inhibitory activity with IC value of 27.3 μg/mL, while compounds , and showed weak PL enzyme inhibitory activity. Further molecular docking simulation exhibited that compound could be well bind with the catalytic pocket of the PL. Besides, compound showed moderate antibacterial activity against with MIC value of 12.5 μg/mL, which was comparable to that of the positive control ampicillin with MIC value of 3.125 μg/mL.
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| http://dx.doi.org/10.1080/14786419.2020.1864632 | DOI Listing |
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