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Recently, in February 2020, we published a study exploring the intestinal absorption and metabolism of oleocanthal (OLC) in rats. A single-pass intestinal perfusion technique (SPIP) was used, involving simultaneous sampling from the luminal perfusate and mesenteric blood. Later, comments on our published paper were released, requesting clarification of specific data. In this detailed reply, we hope to have addressed and clarified all the concerns of A. Kaddoumi and K. El Sayed and that the scientific community will benefit from both the study and the comments it has generated.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765908 | PMC |
http://dx.doi.org/10.3390/pharmaceutics12121221 | DOI Listing |
Ann Pediatr Endocrinol Metab
August 2025
Pediatric Department, School of Medicine, University of Ioannina, Ioannina, Greece.
Dig Liver Dis
September 2025
School of Medicine, Nankai University, 94 Weijin Road, Tianjin, 300071, China. Electronic address:
J Heart Lung Transplant
September 2025
Department of Medicine, University of California, San Francisco, CA; Department of Anesthesia and the Cardiovascular Research Institute, University of California, San Francisco, CA.
Am J Ophthalmol
September 2025
Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital,
Urolithiasis
September 2025
Department of Urology, IRCCS Fondazione Ca' Granda, Policlinico di Milano, Milan, Italy.