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http://dx.doi.org/10.1002/hsr2.203 | DOI Listing |
Rep Biochem Mol Biol
January 2025
Department of Nursing, Erbil Medical Technical Institute, Erbil Polytechnic University, Erbil 44001, Kurdistan Region, Iraq.
Background: Hospitalized Coronavirus Disease 2019 (COVID-19) patients are at a higher risk of bacterial and fungal infections. Procalcitonin is an inflammatory marker that has been suggested for distinguishing between bacterial and viral infections that predicting bacterial co-infection in COVID-19 and serving as a helpful indicator for determining the severity of the illness. This study aimed to evaluate procalcitonin levels and antimicrobial resistance (AMR) among microbial co-infections in hospitalized COVID-19 patients.
View Article and Find Full Text PDFAm J Med Sci
August 2025
Department of Critical Care Medicine, Hongqi Hospital affiliated to Mudanjiang Medical University, Mudanjiang City, Heilongjiang Province 157011, China. Electronic address:
Background: To address the challenge of delayed bacterial infection diagnosis in critically ill COVID-19 patients, we evaluated the performance of serum procalcitonin (PCT), C-reactive protein (CRP), and heparin-binding protein (HBP), and bronchoalveolar lavage fluid HBP as potential biomarkers for guiding antibiotic therapy.
Methods: Patients meeting the inclusion criteria for severe and critical COVID-19 were enrolled as the case group, while age- and gender-matched healthy individuals were selected as the control group. Levels of PCT, CRP, and HBP were measured.
Thorax
June 2025
Department of Population Medicine, Harvard Medical School / Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA
Background: The diagnosis and management of pneumonia is often challenging due to its overlapping clinical presentations with other respiratory illnesses, low pathogen identification rates, and slow turnaround time of conventional bacterial cultures. These factors contribute to both inadequate empiric therapy and overuse of broad-spectrum antibiotics, which can negatively impact outcomes. Recently, multiplex polymerase chain reaction (mPCR) assays capable of rapidly detecting multiple bacterial respiratory pathogens and resistance genes have emerged.
View Article and Find Full Text PDFDiseases
May 2025
Multidisciplinary Research Center of Antimicrobial Resistance, Department of Microbiology, Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania.
Secondary bacterial pneumonia can substantially worsen the clinical trajectory of patients hospitalized for Coronavirus Disease 2019 (COVID-19). This study aimed to characterize bacterial superinfections in COVID-19, including pathogen profiles, resistance patterns, inflammatory responses, severity scores, and ICU admission risk. In a retrospective cohort design, we reviewed 141 patients admitted to a single tertiary-care hospital between February 2021 and December 2024.
View Article and Find Full Text PDFVector Borne Zoonotic Dis
July 2025
Department of respiratory medicine, Beijing Aerospace General Hospital, Beijing, China.
This study aimed to analyze the clinical characteristics of five cases of pneumonia diagnosed using metagenomics next-generation sequencing (mNGS) and to provide help for its diagnosis and treatment. Five patients who were admitted to the department of Respiratory and Critical Care Medicine of Beijing Aerospace General Hospital between June 2020 and December 2021 and diagnosed with pneumonia using mNGS were selected, including one case with severe pneumonia. We analyzed the clinical characteristics, epidemiology, laboratory results, treatment, and prognosis of the five participating patients.
View Article and Find Full Text PDF