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http://dx.doi.org/10.6061/clinics/2020/e2377 | DOI Listing |
PLoS Pathog
September 2025
State Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
Hepatocyte nuclear factor 4 alpha (Hnf4α), a conserved nuclear receptor central to vertebrate liver development and metabolic regulation, emerges here as a pivotal immune regulator in teleosts against complex infectious threats. While its metabolic roles are well-established, Hnf4α's function in bacterial infection, viral infection, and bacterial-viral coinfection-major challenges in global aquaculture-remained uncharacterized. This study reveals that teleost Hnf4α acts as a dual-functional immune checkpoint, essential for combating Aeromonas salmonicida, grass carp reovirus (GCRV), and their coinfection.
View Article and Find Full Text PDFAm J Prev Cardiol
September 2025
Tsimane Health and Life History Project, San Borja, Bolivia.
Background: Greater deposits of epicardial adipose tissue are associated with atrial fibrillation and coronary disease, but have not been studied in subsistence populations.
Methods: We performed CT imaging to measure coronary artery and thoracic aortic calcium (CAC, TAC), epicardial fat thickness (EFT), liver density, and left atrial (LA) anteroposterior diameter and, using a deep learning-enabled software program, epicardial and thoracic fat volume (EFV, TFV), in two remote Amerindian subsistence populations with minimal coronary artery calcification and virtually no atrial fibrillation. We compared 893 adult Tsimane (mean age 58.
J Med Chem
September 2025
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066, Lanzhou University, Lanzhou, Gansu 730000, P. R. China.
Hepatocellular carcinoma (HCC) remains a growing global health threat, necessitating the development of precise molecular probes for its prevention, early diagnosis, and treatment. Glypican-3 (GPC3) is highly expressed in various HCC subtypes and exhibits minimal expression in normal liver tissue, making it a promising biomarker for early-stage HCC diagnosis. Herein, we report a novel cyclic peptide molecular probe, 10P3Me, exhibiting high binding affinity for GPC3, with a of 93.
View Article and Find Full Text PDFAnn Surg Oncol
September 2025
Department of Surgery, Tokushima University, Tokushima, Japan.
Background: Although magnification is an advantage of robotic liver resection (RLR) as it enables precise surgery, the direction of parenchymal dissection, the vascular anatomy, and the tumor location can sometimes be lost. Extended reality (XR) has advantages over other navigation systems in terms of spatial awareness, sharing, and simplicity, and it also has the potential to overcome some of the limitations of RLR. METHODS: In this video, we demonstrate innovative RLR with XR by three separate surgeons.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Crystal Growth Centre, Anna University, Chennai, 600025, Tamil Nadu, India.
Increase in breast cancer has led to the search for systems that can enable, targeted, sustained and prolonged release of drugs while simultaneously reducing the side effects posed by them. In light of this, folic acid-conjugated 5-Fluorouracil and doxorubicin loaded chitosan/Fe₃O₄ (FA-dual@CS/Fe₃O₄) nanocomposite has been synthesized using the chemical method for targeted breast cancer therapy in addition to CS/FeO and dual drug encapsulated CS/FeO. FTIR and XPS studies confirm the successful drug encapsulation and FA conjugation.
View Article and Find Full Text PDF