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Background: Although magnification is an advantage of robotic liver resection (RLR) as it enables precise surgery, the direction of parenchymal dissection, the vascular anatomy, and the tumor location can sometimes be lost. Extended reality (XR) has advantages over other navigation systems in terms of spatial awareness, sharing, and simplicity, and it also has the potential to overcome some of the limitations of RLR. METHODS: In this video, we demonstrate innovative RLR with XR by three separate surgeons. A 63-year-old male patient with two colorectal liver metastases in both segment 5 and 6 respectively, and subsegmentectomy was performed. A console surgeon executes parenchymal dissection with the clamp-crush method. An assistant surgeon uses CUSA to support parenchymal dissection, especially when securing the Glissonean pedicle. A nonsterilized XR surgeon projects the patient's own "hologram" onto the monitor, which is tilted in the same direction as the surgical field to check (1) the approximate tumor location, (2) the correctness of the dissection direction, and (3) the Glisson or hepatic veins that will appear.
Results: The three surgeons continuously share operative information, which also serves as an educational resource for residents and medical students. A total blood loss was 20 ml, and operation time was 178 min. The patient was discharged on postoperative day 8.
Conclusions: This is the world's first report of RLR with XR, which is an innovative approach that can contribute not only to real-time navigation, but also to medical education.
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http://dx.doi.org/10.1245/s10434-025-18297-3 | DOI Listing |
Ann Surg Oncol
September 2025
Department of Surgery, Tokushima University, Tokushima, Japan.
Background: Although magnification is an advantage of robotic liver resection (RLR) as it enables precise surgery, the direction of parenchymal dissection, the vascular anatomy, and the tumor location can sometimes be lost. Extended reality (XR) has advantages over other navigation systems in terms of spatial awareness, sharing, and simplicity, and it also has the potential to overcome some of the limitations of RLR. METHODS: In this video, we demonstrate innovative RLR with XR by three separate surgeons.
View Article and Find Full Text PDFDev Comp Immunol
September 2025
Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA. Electronic address:
Several studies have described immune responses in the teleost brain and meninges during infection, however, fundamental studies that systematically dissect how different regions of the brain maintain immune homeostasis in teleosts are missing. Here we present an in-depth investigation of the immune status of the brain parenchyma and meninges of juvenile rainbow trout (Oncorhynchus mykiss) at the steady state. We dissected four parenchymal brain regions including olfactory bulbs (OB), telencephalon (Tel), optic tectum (OT) and cerebellum (Cer) and its corresponding dorsal meninges.
View Article and Find Full Text PDFMatrix Biol
September 2025
Laboratory for Tissue Microenvironment, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, Japan. Electronic address:
The basement membrane (BM), a specialized extracellular matrix (ECM), provides structural support for epithelial, endothelial, and other parenchymal cells. Once considered a static scaffold, the BM is now recognized as a dynamic and complex nanostructure composed of a diversity of molecules that actively regulate cell behavior and tissue organization. Its molecular composition, assembly, and remodeling are precisely controlled in a tissue- and stage-specific manner, contributing to the regulation of local and global mechanical properties and biochemical signaling.
View Article and Find Full Text PDFInt J Surg Protoc
September 2025
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Introduction: Water-Jet (WJ) dissection is an innovative technique for liver surgery that uses high-pressure saline jets to selectively dissect liver parenchyma while preserving vascular and biliary structures. Compared to the Cavitron Ultrasonic Surgical Aspirator (CUSA), WJ offers advantages such as reduced thermal damage, lower blood loss, and shorter operative times. These benefits are particularly important in living-donor liver transplantation (LDLT), where donor safety and rapid recovery are critical.
View Article and Find Full Text PDFJ Hepatobiliary Pancreat Sci
August 2025
Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
Background/purpose: A standardized liver parenchymal transection method in robotic-assisted liver resection has not yet been established, and the techniques used vary among institutions. We developed a novel transection technique for robotic-assisted liver resection termed "Trac & Pac," which uses maryland bipolar forceps with a gentle stroking motion and strategic traction to progressively expose and dissect the liver parenchyma.
Methods: We described the technical details of "Trac & Pac" and Evaluated its short-term outcomes (2022-2025), comparing them with those of conventional laparoscopic liver resection using the Cavitron Ultrasonic Surgical Aspirator (CUSA) (2018-2022).