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Chronic spontaneous urticaria (CSU) is a benign skin disorder usually responsive to treatment; however, at times it can be difficult to control and become very debilitating. We discuss the case of a woman with CSU that was unresponsive to H1-antihistamines who was treated with omalizumab and became pregnant during omalizumab treatment. We also considered the follow-up of the mother and newborn for 4 years after delivery. Our case report confirms that omalizumab is a safe and effective therapeutic option, after careful evaluations in terms of cost-effectiveness, in pregnant and lactating women with severe chronic urticaria. Assessment throughout follow-up confirmed a regular progression of pregnancy parameters and no adverse reaction was documented in the child from birth to 4 years of age.
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http://dx.doi.org/10.1159/000509179 | DOI Listing |
Clin Transl Gastroenterol
September 2025
Lynda K and David M Underwood Center for Digestive Health, Houston Methodist, Houston, TX, USA.
Introduction: Pharmacological therapies for chronic idiopathic constipation (CIC) are useful, but many patients report dissatisfaction from a lack of efficacy and occurrence of adverse events. The vibrating capsule (VC) is an FDA approved non-pharmacologic, treatment for CIC. However, its long-term usefulness in a community setting is unknown.
View Article and Find Full Text PDFCureus
August 2025
Department of Neurological Surgery, ProMedica Toledo Hospital, Toledo, USA.
Spontaneous intracranial hypotension (SIH) is caused by cerebrospinal fluid leak and has an incidence of approximately five per 100,000 person-years. SIH leads to a range of clinical symptoms, from debilitating postural headaches to subdural hematomas (SDHs). The pathophysiology of the disease is not fully understood, but has garnered interest in recent years.
View Article and Find Full Text PDFInterv Radiol (Higashimatsuyama)
June 2025
Department of Radiology, Oita University Faculty of Medicine, Japan.
This case report describes a 56-year-old woman with autosomal dominant polycystic kidney disease and chronic renal failure who underwent transcatheter arterial embolization with N-butyl-2-cyanoacrylate-Lipiodol before renal transplantation. Both kidneys were significantly enlarged, necessitating transcatheter arterial embolization to reduce renal volume and create space for transplantation. The right kidney volume decreased from 2520 to 1150 mL within 9 months after transcatheter arterial embolization, enabling successful transplantation.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Marine College, Shandong University, Weihai, 264209, China; Shandong Laboratory of Advanced Materials and Green Manufacturing, Yantai, 265599, China. Electronic address:
The treatment of chronic hard-to-heal wounds has become a major medical and public health problem worldwide. The search for novel and efficient wound healing dressings is crucial because of the complex mechanisms of wound genesis and of the inability to spontaneously repair. Many inherent properties of organisms in nature and their intrinsic molecular mechanisms have inspired researchers to design biomimetic hydrogel wound dressings to treat chronic hard-to-heal wounds.
View Article and Find Full Text PDFArch Med Res
September 2025
Department of Gastroenterology, General Hospital of Northern Theater Command, Teaching Hospital of Shenyang Pharmaceutical University, Shenyang, China; Department of Clinical Pharmacy, Shenyang Pharmaceutical University, Shenyang, China. Electronic address:
Cirrhosis is the terminal stage of various chronic liver diseases, and its decompensated stage is mainly characterized by serious complications, such as hepatic encephalopathy, ascites, spontaneous bacterial peritonitis, and gastrointestinal bleeding. Gut microbial dysbiosis is prevalent in patients with cirrhosis. Considering the bidirectional regulation of the gut-liver axis, dysbiosis is closely related to the development and progression of liver cirrhosis.
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