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http://dx.doi.org/10.1186/s12348-020-00222-2 | DOI Listing |
Front Neurol
August 2025
Nuffield Department of Clinical Neurosciences, Oxford University Centre For Integrative Neuroimaging, Oxford, United Kingdom.
Introduction: Amblyopia is a neurodevelopmental visual disorder treated with occlusion or pharmacological penalization of the dominant, non-amblyopic eye in early childhood. After early childhood, efficacy of occlusion therapy is limited due to a reduction in neuronal plasticity, and no mainstay clinical treatment is available. Selective serotonin reuptake inhibitors (SSRIs) have been hypothesized to enhance neuroplasticity in the adult brain, thereby facilitating improvements in amblyopia.
View Article and Find Full Text PDFSurv Ophthalmol
September 2025
Department of Surgery, Division of Ophthalmology, McMaster University, Hamilton, Ontario, Canada; Singapore Eye Research Institute, Singapore National Eye Center, Singapore. Electronic address:
This systematic review examines the prognostic value of baseline optical coherence tomography (OCT) biomarkers in predicting visual acuity (VA) outcomes for eyes with macular edema secondary to retinal vein occlusions (RVO) treated with anti-VEGF therapies, steroids, laser photocoagulation, or combination treatments. VA predictions at 6, 12, and 24 months post-treatment were assessed using a narrative synthesis approach and vote counting based on effect direction relative to a minimal clinically important difference. Certainty of evidence was evaluated using GRADE guidelines.
View Article and Find Full Text PDFSurv Ophthalmol
September 2025
Department of Ophthalmology, Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Weifang 261041, China.
Lipid metabolism plays a critical role in maintaining normal physiological functions and is strongly linked to the pathogenesis of ocular vascular diseases. This review examines how disorders of lipid metabolism drive progression in ocular vascular diseases, including diabetic retinopathy, age-related macular degeneration, retinal vascular occlusive diseases, and retinopathy of prematurity. These disorders are classified as a related group due to their common feature of impaired ocular vascularization.
View Article and Find Full Text PDFOphthalmol Glaucoma
September 2025
NIHR Moorfields Biomedical Research Centre, Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, England; Discipline of Clinical Ophthalmology and Eye Health, University of Sydney, Sydney, New South Wales, Australia.
Purpose: To compare the long-term safety of MicroShunt implantation with trabeculectomy in eyes with primary open-angle glaucoma (POAG).
Methods: This was a 3-year observational extension of a 2-year prospective randomized trial comparing clinical outcomes of MicroShunt implantation with trabeculectomy, both augmented with mitomycin C. Adverse events (AEs), intraocular pressure (IOP), and IOP-lowering medication use were recorded 36, 48, and 60 months after initial randomization.
Int Ophthalmol
September 2025
Ophthalmology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, 32511, Menoufia, Egypt.
Purpose: To evaluate the role of optical coherence tomography angiography (OCTA) in differentiating ischemic and non-ischemic central retinal vein occlusion (CRVO).
Methods: This prospective observational study included 72 eyes with CRVO (36 ischemic, 36 non-ischemic), all presenting with macular edema. Participants underwent clinical evaluation, fundus fluorescein angiography (FFA), and OCTA imaging.