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Article Abstract
Background: The significance of () infection and atrophic gastritis (AG) in the prevalence of colorectal adenomas has been examined in a limited number of studies. However, these studies reported disputed conclusions.
Aim: To investigate whether infection, AG, and -related AG increase the risk of colorectal adenomas.
Methods: This retrospective cross-sectional study included 6018 health-check individuals. The relevant data for physical examination, laboratory testing, C-urea breath testing, gastroscopy, colonoscopy and histopathological examination of gastric and colorectal biopsies were recorded. Univariate and multivariate logistic regression analyses were performed to determine the association between -related AG and colorectal adenomas.
Results: Overall, 1012 subjects (16.8%) were diagnosed with colorectal adenomas, of whom 143 (2.4%) had advanced adenomas. Among the enrolled patients, the prevalence of infection and AG was observed as 49.5% (2981/6018) and 10.0% (602/6018), respectively. Subjects with infection had an elevated risk of colorectal adenomas (adjusted odds ratio [OR] of 1.220, 95% confidence interval (CI): 1.053-1.413, = 0.008) but no increased risk of advance adenomas (adjusted OR = 1.303, 95%CI: 0.922-1.842, = 0.134). AG was significantly correlated to an increased risk of colorectal adenomas (unadjusted OR = 1.668, 95%CI: 1.352-2.059, < 0.001; adjusted OR = 1.237, 95%CI: 0.988-1.549, = 0.064). infection accompanied by AG was significantly associated with an increased risk of adenomas (adjusted OR = 1.491, 95%CI: 1.103-2.015, = 0.009) and advanced adenomas (adjusted OR = 1.910, 95%CI: 1.022-3.572, = 0.043).
Conclusion: -related AG was associated with a high risk of colorectal adenomas and advanced adenomas in Chinese individuals.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545385 | PMC |
| http://dx.doi.org/10.3748/wjg.v26.i37.5682 | DOI Listing |
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