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Article Abstract
We aimed to identify and characterize extended-spectrum β-lactamase (ESBL)-and/or plasmid-mediated AmpC β-lactamase (pAmpC)-producing isolated from healthy broiler chickens slaughtered for human consumption in Korea. A total of 332 isolates were identified from 339 cloacal swabs in 2019. More than 90% of the isolates were resistant to multiple antimicrobials. ESBL/pAmpC-production was noted in 14% (46/332) of the isolates. Six of the CTX-M-β-lactamase-producing isolates were found to co-harbor at least one plasmid-mediated quinolone resistance gene. We observed the co-existence of and genes in the same isolate for the first time in Korea. Phylogenetic analysis demonstrated that the majority of -carrying isolates belonged to subgroup D. Conjugation confirmed the transferability of and genes, as well as non-β-lactam resistance traits from 60.9% (28/46) of the ESBL/pAmpC-producing isolates to a recipient J53. The , , and elements were detected in the upstream or downstream regions. The and genes mainly belonged to the IncI1, IncHI2, and/or IncFII plasmids. Additionally, the majority of ESBL/pAmpC-producing isolates exhibited heterogeneous PFGE profiles. This study showed that healthy chickens act as reservoirs of ESBL/pAmpC-producing that can potentially be transmitted to humans.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564670 | PMC |
| http://dx.doi.org/10.3390/microorganisms8091434 | DOI Listing |
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