Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: This population-based retrospective study compares the efficacy of cisplatin (cis-RT) vs cetuximab (cetux-RT) with concurrent radiation as definitive treatment in patients with oropharyngeal carcinoma (OPC).
Methods: Patients with OPC treated in Alberta with cis-RT or cetux-RT between 2006 and 2016 were evaluated. Median disease-free survival (DFS) and overall survival (OS) were assessed using the Kaplan-Meier method. Multivariable analysis (MVA) was completed with a Cox proportional hazards model.
Results: Among 546 patients with OPC, 431 (78.9%) received cis-RT and 115 (21.1%) cetux-RT. Patients treated with cetux-RT were more likely to develop a recurrence after treatment compared to cis-RT (25% vs 15%, P = .01). On MVA, current smoking, human papillomavirus (HPV)-negative status, higher Charlson comorbidity index (CCI), T-stage, and cetux-RT predicted for worse DFS and OS. Outcomes in older patients with a higher CCI still favored cis-RT.
Conclusions: Our data reaffirm results from randomized studies showing better survival outcomes with cis-RT compared to cetux-RT even among those who are >65 with CCI ≥3.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/hed.26469 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Synchronous Human Papillomavirus (HPV)-Positive Oropharyngeal Carcinoma and Occult Papillary Thyroid Carcinoma: A Case Report and Review of the Literature.
Cureus
August 2025
Department of Otolaryngology - Head and Neck Surgery, China Medical University Hospital, Taichung, TWN.
Synchronous malignancies involving the oropharynx and thyroid gland are rare. We report the case of a 52-year-old female diagnosed with human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) with a concurrent, clinically occult papillary thyroid carcinoma (PTC). The patient initially presented with HPV-associated OPSCC and concerns for cervical lymphadenopathy, presumed to be linked to regional metastasis from the oropharyngeal primary.
View Article and Find Full Text PDFProspective Evaluation of Patient Priorities in HPV-Driven Oropharyngeal Cancer Using the Chicago Priorities Scale: Considerations for Future Clinical Trial Design.
Int J Radiat Oncol Biol Phys
September 2025
Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia; Department of Health Services Research, Peter MacCallum Cancer Centre, Melbourne, Australia; Department of Nursing, Faculty of Medicine, Dentistry, and Health Sciences, The University of Melbourne, Melbourne,
Purpose: This study examined head and neck cancer treatment outcome priorities in patients with human papillomavirus-associated oropharyngeal cancer (HPVOPC) before and 12 months (12m) after (chemo)radiotherapy ([C]RT).
Methods And Materials: Eligible patients were diagnosed with HPVOPC suitable for curative-intent primary [C]RT. Study data included responses to a modified version of the Chicago Priorities Scale (CPS-modified) and select items from the MDASI Head and Neck Cancer Module (MDASI-HN).
De-escalated adjuvant radiotherapy versus standard adjuvant treatment for human papillomavirus-associated oropharyngeal squamous cell carcinoma (MC1675): a phase 3, open-label, randomised controlled trial.
Lancet Oncol
September 2025
Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.
Background: Standard adjuvant chemoradiotherapy (60-66 Gy) following surgery for HPV-associated oropharyngeal squamous cell carcinoma has excellent oncological control but high treatment morbidity. We aimed to compare toxicity of a 30-36 Gy regimen of de-escalated adjuvant radiotherapy and standard of care treatment.
Methods: We did this phase 3, open-label, randomised controlled trial in two academic sites in the USA.
Artificial intelligence in dysphagia since the 21st century: a bibliometric and visualization study.
Front Med (Lausanne)
August 2025
Peking University School of Nursing, Beijing, China.
Background: The fields of dysphagia is progressively acknowledging the transformative capacity of artificial intelligence (AI). The implementation of this technology is profoundly impacting research directions, clinical practices, and healthcare systems. However, existing studies remain scattered and predominantly focus on specific techniques or case applications, lacking a systematic synthesis of global research output, influential contributors, collaboration networks, and evolving thematic trends.
View Article and Find Full Text PDFCausal Association Between Epidermal Growth Factor and Laryngeal/Oropharyngeal Cancer: A 2-Sample Mendelian Randomization Analysis.
J Craniofac Surg
September 2025
Department of Otolaryngology and Head and Neck Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine.
The human epidermal growth factor (EGF)-related proteins are thought to play a key role in the pathogenesis of laryngeal cancer (LC) and oropharyngeal cancer (OPC). The aim of this study was to investigate the potential causal relationship between them. A 2-sample Mendelian randomization (MR) analysis utilizing genome-wide association studies (GWAS) data uniquely evaluated causal relationships between EGF-related proteins and both LC and OPC.
View Article and Find Full Text PDF