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http://dx.doi.org/10.1097/CM9.0000000000001028 | DOI Listing |
Eur Arch Psychiatry Clin Neurosci
September 2025
School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Concerns over the mental health among young people have been increasing recently. We aimed to estimate the burdens of mental disorders, substance use disorders (SUDs), and self-harm at global, regional and national levels among adolescents and young adults aged 10-24 years from 1990 to 2021. Incidence, prevalence, and disability-adjusted life years (DALYs) of mental disorders, SUDs, and self-harm among young people were examined by age, sex, region, and country/territory.
View Article and Find Full Text PDFAutophagy
September 2025
Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Immune checkpoint inhibitors (ICIs) can re-active the immune response and induce a complete response in mismatch repair-deficient and microsatellite instability-high (dMMR/MSI-H) colorectal cancer (CRC). However, most CRCs exhibit proficient mismatch repair and microsatellite stable (pMMR/MSS) phenotypes with limited immunotherapy response because of sparse intratumoral CD8 T-lymphocyte infiltration. Cellular senescence has been reported to involve immune cell infiltration through a senescence-associated secretory phenotype (SASP).
View Article and Find Full Text PDFInt J Surg
September 2025
First Clinical Medical College of Gannan Medical University, Ganzhou, Jiangxi, China.
Front Plant Sci
August 2025
College of Agriculture, South China Agricultural University, Guangzhou, China.
Tobacco ( L.) is well-known as an economic crop whose quality is evaluated according to its aroma quality. Researchers have found that selenium application can increase the aroma quality of tobacco, but until now, its mechanism is still unclear.
View Article and Find Full Text PDFPrev Med Rep
October 2025
Guangxi Orthopedic Hospital, Nanning 530012, China.
Objective: Negative emotions during adolescence constitute a significant public health challenge requiring theoretically-grounded intervention approaches. This investigation examined sequential mediation mechanisms whereby physical exercise influences adolescent negative emotions through psychological benefits and social self-efficacy pathways, integrating neurobiological and social-cognitive theoretical frameworks.
Methods: Cross-sectional analysis of 1471 Chinese adolescents (Mean age = 13.