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http://dx.doi.org/10.1371/journal.ppat.1008663 | DOI Listing |
PLoS One
September 2025
School of Animation and Digital Arts, Communication University of China, Nanjing, China.
Instruction in coding for children has emerged as a significant means of fostering computational thinking, with gamification serving a crucial reinforcing function in this educational process. This experimental study integrates four principal gamification elements-role-playing, rewards, challenges, and cooperation-into unplugged children's coding education tools to examine their impacts on children's flow experience and learning engagement. Under the theoretical framework of Stimulus-Organism-Response (S-O-R), researchers developed an unplugged coding education prototype named "Coding Adventure," employing an explanatory sequential mixed-methods approach with 295 Chinese elementary students (aged 8-10 years).
View Article and Find Full Text PDFMayo Clin Proc
September 2025
Stanford University School of Medicine and Department of Medicine, Stanford Medicine, Stanford, CA.
This article is the second chapter in a series of 5 articles considering the different stages of physicians' career life cycle. The present article focuses on exploring the early career phase. The early career phase represents an exciting time when physicians establish themselves in independent practice and develop their professional identity.
View Article and Find Full Text PDFJ Chem Inf Model
September 2025
Psivant Therapeutics, 451 D Street, Boston, Massachusetts 02210, United States.
Generative modeling with artificial intelligence (GenAI) offers an emerging approach to discover novel, efficacious, and safe drugs by enabling the systematic exploration of chemical space and to design molecules that are synthesizable while also having desirable drug properties. However, despite rapid progress in other industries, GenAI has yet to demonstrate clear and consistent value in prospective drug discovery applications. In this Perspective, we argue that the ultimate goal of generative chemistry is not just to generate "new" or "interesting" molecules, but to generate "beautiful" molecules─those that are therapeutically aligned with the program objectives and bring value beyond traditional approaches.
View Article and Find Full Text PDFOptically pumped polymer nanolasers drive the development of integrated optoelectronic devices. Introduction of surface plasmon into nanolasers can effectively enhance the local electromagnetic field in the optical pumping processes. However, significant quenching effects on organic fluorescence emissions bring the challenge in high-efficient lasing from the distributed feedback (DFB) nano-device loaded with noble metal particles.
View Article and Find Full Text PDFFront Health Serv Manage
August 2025
Doug Niedzwiecki, FACHE,is senior vice president UCI Health Community Network at UCI Health in Orange, California.
University of California (UCI) Health acquired an integrated healthcare delivery system from Tenet Healthcare in March 2024. The acquisition, which included four hospitals and added 858 beds to the system, was a pivotal move toward pursuing the organization's commitment to the long-term health needs of the region and progressing UCI Health's strategic priorities to improve health, increase sustainability, and transform healthcare. Following the acquisition, UCI Health embarked on a journey to integrate the system.
View Article and Find Full Text PDF