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http://dx.doi.org/10.1016/j.tree.2020.07.016 | DOI Listing |
PLoS Biol
September 2025
Centre for Bacterial Resistance Biology (CBRB), Imperial College London, London, United Kingdom.
Antimicrobial resistance (AMR) is a growing problem that should be ignored at our peril. The development of new diagnostics, drugs, and vaccines to tackle AMR faces technical difficulties and challenges that need to be addressed urgently.
View Article and Find Full Text PDFStat Med
March 2025
Division of Biostatistics, Department of Population Health, New York University School of Medicine, New York, New York, USA.
Platform trials are multi-arm designs that simultaneously evaluate multiple treatments for a single disease within the same overall trial structure. Unlike traditional randomized controlled trials, they allow treatment arms to enter and exit the trial at distinct times while maintaining a control arm throughout. This control arm comprises both concurrent controls, where participants are randomized concurrently to either the treatment or control arm, and non-concurrent controls, who enter the trial when the treatment arm under study is unavailable.
View Article and Find Full Text PDFFront Psychol
November 2024
Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, United States.
Each one of us is confronted with warnings of danger or threats to wellbeing in our everyday life, whether in the form of certain road signs, Public Service Announcements, ominous changes in bodily functioning, or cautionary tales heard from family or friends. There is great inter-individual variation in how people respond to such threats, with some people habitually tending to ignore or dismiss them, often to their peril. The first purpose of the present paper is to review several studies showing that individuals-most often men-who score very low on measures of trait anxiety are more likely to engage in behaviors that could jeopardize their physical wellbeing.
View Article and Find Full Text PDFEur Heart J Case Rep
October 2024
Department of Cardiology, Lister Hospital, East & North Hertfordshire NHS Trust, Coreys Mill Lane, Stevenage SG1 4AB, UK.
Background: Blunt chest trauma (BCT) presenting to the emergency department is common and may cause life-threatening cardiac complications. Whilst complications causing haemodynamic instability are generally detected promptly, others may present late with long-term consequences. We describe a rare, serious complication of BCT presenting five years after a road traffic accident (RTA).
View Article and Find Full Text PDFIndian J Dermatol Venereol Leprol
May 2024
Department of Dermatology, Atal Bihari Vajpayee Institute of Medical Sciences and Dr Ram Manohar Lohia Hospital, Delhi, India.