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The scientific community has corroborated the numerous beneficial activities of fucoxanthin, such as its antioxidant, anti-inflammatory, anticancer or neuroprotective effects, among others. These properties have attracted the attention of nutraceutical, cosmetic and pharmacological industries, giving rise to various possible applications. Fucoxanthin may be chemically produced, but the extraction from natural sources is considered more cost-effective, efficient and eco-friendly. Thus, identifying suitable sources of this compound and giving a general overview of efficient extraction, quantification, purification and stabilization studies is of great importance for the future production and commercialization of fucoxanthin. The scientific research showed that most of the studies are performed using conventional techniques, but non-conventional techniques begin to gain popularity in the recovery of this compound. High Performance Liquid Chromatography (HPLC), Nuclear Magnetic Resonance (NMR) and spectroscopy techniques have been employed in the quantification and identification of fucoxanthin. The further purification of extracts has been mainly accomplished using purification columns. Finally, the stability of fucoxanthin has been assessed as a free molecule, in an emulsion, or encapsulated to identify the variables that might affect its further industrial application.
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http://dx.doi.org/10.3390/foods9081113 | DOI Listing |
Antioxidants (Basel)
August 2025
Department of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam 13488, Republic of Korea.
Ferroptosis is an iron-dependent form of regulated cell death marked by lipid peroxidation in polyunsaturated phospholipids. In head and neck cancer (HNC), where resistance to chemotherapy and immunotherapy is common, ferroptosis offers a mechanistically distinct strategy to overcome therapeutic failure. However, cancer cells often evade ferroptosis via activation of nuclear factor erythroid 2-related factor 2 (Nrf2), a key regulator of antioxidant and iron-regulatory genes.
View Article and Find Full Text PDFFront Pharmacol
July 2025
Laboratory of Stem Cell Transplantation, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Fucoxanthin is a natural carotenoid that has remarkable anti-tumor effects and an excellent safety profile. Here, we combined molecular docking, dynamics simulations, and functional assays (CCK-8, flow cytometry, glucose/ATP detection) to decipher the mechanism of Fucoxanthin on FLT3-ITD AML cells. Fucoxanthin (25 μM) reduced MOLM13 (FLT3-ITD) cell viability by 63.
View Article and Find Full Text PDFAnimals (Basel)
May 2025
Collaborative Innovation Center for Zhejiang Marine High-Efficiency and Healthy Aquaculture, Ningbo University, Ningbo 315211, China.
The pigmentation and coloration of are primarily determined by the type and concentration of dietary carotenoids, with carotenoid-rich macroalgae serving as effective dietary supplements to enhance pigment accumulation and improve commercial quality. Five experimental diets were formulated with 3% brown algae (, SJ group; , SF group), red algae (, NH group), or 0.1% purified carotenoids (zeaxanthin, ZT group; fucoxanthin, FX group).
View Article and Find Full Text PDFFood Res Int
August 2025
Hainan Institute of Northwest A&F University, Sanya, Hainan Province 572025, China; College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China. Electronic address:
Fucoxanthin (FUC), a carotenoid naturally occurring in marine environments, has demonstrated various nutritional benefits. However, its application in the food industry is limited due to its inherent instability. This study aims to evaluate the ability of two types of lactoferrin (LF)-carboxymethyl chitosan (CMCS) complexes to encapsulate and stabilize FUC.
View Article and Find Full Text PDFInt J Biol Macromol
June 2025
CIIDIR Unidad Oaxaca, Instituto Politécnico Nacional, Hornos 1003, Santa Cruz Xoxocotlán, Oaxaca 71230, Mexico. Electronic address:
Since 2011, the Mexican Caribbean has experienced periodic influxes of Sargassum biomass, leading to severe ecological and economic impacts. In this study, sodium alginate was isolated using a multistage methodology that included ultrafiltration to purify and concentrate the biopolymer, yielding 28 %. FTIR analysis confirmed the presence of typical absorption bands for carboxylate groups and acid sugars, with a correlation coefficient of 0.
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