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http://dx.doi.org/10.1523/JNEUROSCI.1250-20.2020 | DOI Listing |
Orthop Rev (Pavia)
September 2025
Introduction/background: Complex articular fractures around the knee in the elderly patient present an ongoing challenge regarding optimal treatment. While extensive research has evaluated immediate arthroplasty following fracture of the proximal femur, distal femur, proximal humerus, and elbow, relatively little focus has been given to immediate arthroplasty following complex tibia plateau fractures.
Methods: As seen with many other fractures, arthroplasty can shorten recovery and hospital stay and allow early weight-bearing with improved mobility while minimizing complications and possible future conversion arthroplasty cost.
Transl Neurosci
January 2025
Department of Neurology, Hebei General Hospital, Shijiazhuang, Hebei, P.R. China.
Objectives: Excessive neuroinflammatory responses represent a key pathological mechanism in cerebral small vessel disease (CSVD). Dl-3--butylphthalide (NBP), a compound previously demonstrated to possess anti-inflammatory properties in ischemic stroke, was investigated for its potential therapeutic effects in a rodent model of CSVD. This study aimed to elucidate the neuroprotective mechanisms of NBP in CSVD pathogenesis.
View Article and Find Full Text PDFACS Omega
September 2025
Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Tacrolimus belongs to the BCS class-II drug family and exhibits poor water solubility, which leads to poor bioavailability. Furthermore, since tacrolimus is an immunosuppressant, it is essential to maintain its therapeutic concentration for a greater period of time to confirm its effectiveness against transplant rejection. Therefore, to achieve the objective of the sustained release of the drug with a suitable amount of entrapment efficiency, pH-sensitive tacrolimus-loaded superabsorbent hydrogels using chitosan have been prepared.
View Article and Find Full Text PDFJ Educ Health Promot
July 2025
Research Center, Executive Administration of Research and Innovation, King Abdullah Medical City, Makkah, Saudi Arabia.
Background: The Saudi Commission for Health Specialties (SCFHS) accredits postgraduate medical education programs in Saudi Arabia to ensure they provide quality training that meets professional outcomes per national and international standards. Research activities should be tailored to meet the training needs of postgraduate trainees to bridge the gap between research and clinical practice. These activities should assist trainees in selecting the appropriate methodology for their research, gathering and interpreting data, and evaluating the outcomes of previous research before clinical implementation.
View Article and Find Full Text PDFJ Educ Health Promot
July 2025
Department of Medical Imaging Technology, Manipal College of Health Professions Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Background: Obesity and hypertension are widespread health issues associated with changes in brain structure and cognitive function, especially in individuals who lead sedentary lifestyles. This research examines the connections between obesity, high blood pressure, brain structure, and cognitive abilities in people who lead a sedentary lifestyle.
Materials And Methods: The study involved 90 individuals aged between 18 and 35 years, who were categorized into three groups: control (n = 30), obese (n = 30), and hypertensive (n = 30).