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Closure of chronic lower extremity wounds is important for minimizing the risk of infection and amputation in a very high-risk population. Developments in tissue cultures and matrix therapies have shown promise in enhancing healing. The use of autologous homologous skin constructs in wound treatment may enable the regeneration of functional dermal structures. We present the case of a chronic medial heel ulcer that dehisced following intraoperative debridement, which was subsequently treated using a combination of an autologous homologous skin construct and total contact casting. This case emphasizes the importance of proper offloading for healing and preventing recurrence of lower extremity wounds.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416823 | PMC |
http://dx.doi.org/10.1093/omcr/omaa058 | DOI Listing |
Int J Mol Sci
August 2025
Reconstructive Orthopaedic Surgery and Innovative Techniques-Musculoskeletal Tissue Bank, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
Peripheral nerve injuries affect over one million individuals annually worldwide due to various causes such as trauma, metabolic disorders, and autoimmune diseases. While autologous nerve grafting remains the gold standard for treating large-gap nerve injuries, its limitations, including limited tissue availability, donor site morbidity, infection risk, and suboptimal functional recovery, have spurred interest in alternative approaches. Among these, allogeneic nerve grafting has emerged as a promising option, offering structural and functional advantages due to the native architecture of donor nerves.
View Article and Find Full Text PDFTransfusion
August 2025
Blood Bank, Grupo Gestor de Serviços de Hemoterapia-Grupo GSH, São Paulo, Brazil.
Background: The management of intraoperative autologous blood salvage (ABS) quality is essential to ensure safety and outcomes; although publications on this subject are scarce. We evaluated a standardized program of ABS quality control for cardiac and evaluated surgery predictors of mortality in this population.
Methods: Data from a multicenter retrospective study conducted in 27 institutions from January 2021 to December 2023 were analyzed.
Transl Lung Cancer Res
July 2025
Cancer Center, Department of Medical Oncology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China.
Background: Cancer patients relapsing with leptomeningeal metastases (LM) but without extracranial lesions are usually unsuitable for cellular immunotherapy with tumor-infiltrating lymphocytes (TILs) owing to lack of tumor tissue. TILs generated from heavily pretreated patients, especially those with non-melanoma cancer often have anergic effects and are less toxic to tumors, limiting the antitumor efficacy of lymphocyte-based therapy. Whether using autologous tumor tissue banked in advance addresses the dilemma has not been explored.
View Article and Find Full Text PDFEur J Orthop Surg Traumatol
August 2025
Tianjin Hospital, Tianjin, China.
Purpose: Anterior cruciate ligament (ACL) injury is a common sports-related injury that often requires surgical intervention. The two main types of grafts used in ACL reconstruction are autografts and allografts. Two types of transplants have their own advantages in different aspects, so the choice of graft type is a matter of ongoing debate among orthopedic surgeons.
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