Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
This study aimed to assess regenerative treatment protocols for maturogenesis of immature teeth with apical periodontitis in dogs. Apical periodontitis was induced in immature premolars of 8 mongrel dogs teeth that were divided into 5 groups; regeneration via blood clotting (REG group); chitosan loaded with demineralised bone matrix (REG-CD group); chitosan loaded with dexamethazone corticosteroid (REG-CC group); and positive and negative control groups. All groups showed comparable apical hard tissue formation and significantly different from the control group. Results also showed decrease in inflammatory tissue reaction, bone resorption and periodontal ligament thickness. Tissue reaction and inflammatory infiltrates were significantly less in REG-CC group compared to others. Other parameters showed no significant difference. In conclusion, regenerative endodontic techniques using chitosan-based formulations have the potential to be used as an alternative for root maturation in teeth with apical periodontitis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/aej.12426 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Retrospective analysis of common diseases in pediatric oral emergency patients of Ningbo.
Front Dent Med
August 2025
Department of Otorhinolaryngology Head and Neck Surgery, Ningbo Yinzhou No. 2 Hospital, Ningbo, Zhejiang, China.
Background: With the increase in the resident population and the number of children in Ningbo, as well as the growing demand for oral health care, the number of children's dental emergencies has been increasing year by year. This trend not only increases the pressure on medical resources, but also puts higher demands on the level of children's oral emergency care. In order to better guide the diagnosis and treatment of common and frequent diseases in paediatric oral emergency care, and to improve the efficiency of the use of medical resources.
View Article and Find Full Text PDFEffect of Oral Pathogens Associated With Pulpitis and Apical Periodontitis on Odontogenic Mesenchymal Stem Cells.
Stem Cells Int
August 2025
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials
Dental mesenchymal stem cells (MSCs) play an essential role in the development of immature permanent teeth. Bacterial infection of the pulp and periapical tissues of immature permanent teeth, the associated oral pathogens, and their virulence factors affect the viability, proliferation, differentiation, and cytokine secretion of MSCs. Bacteria and virulence factors can also trigger an inflammatory response that induces pro-inflammatory cytokine secretion and destroys odontogenic MSCs in the pulp and periapical region, negatively affecting the development of immature permanent teeth.
View Article and Find Full Text PDFIdentification of cuproptosis-related genes in chronic apical periodontitis based on bulk and single-cell RNA sequencing analyses and experimental validation.
Front Immunol
September 2025
Department of Stomatology, the Affiliated Hospital of Qingdao University, Qingdao, China, School of Stomatology, Qingdao University, Qingdao, China.
Background: Chronic apical periodontitis (CAP) is a prevalent oral inflammatory disease, yet the complex mechanisms underlying its etiology remain unclear. A recently identified cell death pathway known as cuproptosis may be linked to this condition.
Methods: Differentially expressed cuproptosis-related genes (DE-CRGs) were identified by integrating human CAP dataset (GSE237398) with health control (HC) dataset (GSE223924) from the Gene Expression Omnibus (GEO) database.
Sexual Dimorphism in Apical Periodontitis Severity Detected by CBCT.
J Endod
September 2025
University of Texas Health at San Antonio, Department of Endodontics; San Antonio, Texas, USA. Electronic address:
Introduction: Although several elegant studies have reported apical periodontitis prevalence in different populations, far less is known about its associated bone loss and its correlation to sex and age. Thus, this study investigated the impact of sex and age differences on the severity of apical periodontitis (AP) using cone-beam computed tomography (CBCT) and a volumetric periapical index (CBCT-PAI).
Material And Methods: CBCT scans of 401 patients (1,027 teeth) were analyzed by calibrated examiners in CBCTPAI.
Robot-assisted Minimally Invasive Management of a Calcified Mandibular Lateral Incisor: A Case Report.
Int Dent J
September 2025
Department of Endodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, China. Electronic address:
Introduction And Aims: Calcified root canals in mandibular anterior teeth present significant therapeutic challenges due to their narrow anatomy and minimal tolerance for procedural errors. This case report demonstrates the successful integration of robot-assisted navigation with an ultra-fine bur to address these challenges.
Methods: A 44-year-old male presented with symptomatic chronic apical periodontitis and pulp calcification in a mandibular lateral incisor, 20 years after orthodontic treatment.