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Emotion, mood, and stress recognition (EMSR) has been studied in laboratory settings for decades. In particular, physiological signals are widely used to detect and classify affective states in lab conditions. However, physiological reactions to emotional stimuli have been found to differ in laboratory and natural settings. Thanks to recent technological progress (e.g., in wearables) the creation of EMSR systems for a large number of consumers during their everyday activities is increasingly possible. Therefore, datasets created in the wild are needed to insure the validity and the exploitability of EMSR models for real-life applications. In this paper, we initially present common techniques used in laboratory settings to induce emotions for the purpose of physiological dataset creation. Next, advantages and challenges of data collection in the wild are discussed. To assess the applicability of existing datasets to real-life applications, we propose a set of categories to guide and compare at a glance different methodologies used by researchers to collect such data. For this purpose, we also introduce a visual tool called Graphical Assessment of Real-life Application-Focused Emotional Dataset (GARAFED). In the last part of the paper, we apply the proposed tool to compare existing physiological datasets for EMSR in the wild and to show possible improvements and future directions of research. We wish for this paper and GARAFED to be used as guidelines for researchers and developers who aim at collecting affect-related data for real-life EMSR-based applications.
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http://dx.doi.org/10.3389/fpsyg.2020.01111 | DOI Listing |
Apoptosis
September 2025
School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
A defining hallmark of malignant tumours lies in their pronounced resistance to programmed cell death mechanisms. This intrinsic resilience enables cancer cells to circumvent physiological clearance, thereby sustaining unchecked proliferation and survival. Emerging research has revealed that metabolic dysregulation can precipitate a distinctive form of programmed cell death, termed metabolism-linked regulated cell death (RCD), establishing it as a novel paradigm of cellular self-elimination.
View Article and Find Full Text PDFMol Biol Rep
September 2025
Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran.
Background: Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide. The tumor microenvironment (TME), particularly the interactions between endothelial cells and cancer-associated fibroblasts (CAFs), plays a pivotal role in promoting tumor growth, angiogenesis, oxidative stress, and therapy resistance. The HUVEC-fibroblast co-culture model closely mimics stromal-endothelial interactions observed in CRC, enabling mechanistic insights not achievable in monocultures.
View Article and Find Full Text PDFMol Biol Rep
September 2025
Chitkara College of Pharmacy, Chitkara University, Rajpura, 140401, Punjab, India.
Neuroinflammation, a vital protective response for tissue homeostasis, becomes a detrimental force when chronic and dysregulated, driving neurological disorders like Alzheimer's, Parkinson's, and Huntington's diseases. Potassium (K) channels maintain membrane potential and cellular excitability in neurons and glia within the intricate CNS signaling network. Neuronal injury or inflammation can disrupt K channel activity, leading to hyperexcitability and chronic pain.
View Article and Find Full Text PDFMol Biomed
September 2025
National Key Laboratory of Immunity and Inflammation & Institute of Immunology, College of Basic Medical Sciences, Naval Medical University, Shanghai, 200433, China.
Dendritic cells (DCs) play a central role in coordinating immune responses by linking innate and adaptive immunity through their exceptional antigen-presenting capabilities. Recent studies reveal that metabolic reprogramming-especially pathways involving acetyl-coenzyme A (acetyl-CoA)-critically influences DC function in both physiological and pathological contexts. This review consolidates current knowledge on how environmental factors, tumor-derived signals, and intrinsic metabolic pathways collectively regulate DC development, subset differentiation, and functional adaptability.
View Article and Find Full Text PDFBioimpacts
August 2025
Electrical Department, Shahrood University of Technology, Shahrood, Iran.
Introduction: Accurate and non-invasive blood glucose estimation is essential for effective health monitoring. Traditional methods are invasive and inconvenient, often leading to poor patient compliance. This study introduces a novel approach that leverages systolic-diastolic framing Mel-frequency cepstral coefficients (SDFMFCC) to enhance the accuracy and reliability of blood glucose estimation using photoplethysmography (PPG) signals.
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