Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Ionic liquids derived from classical antimalarials are emerging as a new approach towards the cost-effective rescuing of those drugs. Herein, we disclose novel surface-active ionic liquids derived from chloroquine and natural fatty acids whose antimalarial activity in vitro was found to be superior to that of the parent drug. The most potent ionic liquid was the laurate salt of chloroquine, which presented IC values of 4 and 110 nM against a chloroquine-sensitive and a chloroquine-resistant strain of , respectively, corresponding to an 11- and 6-fold increase in potency as compared to the reference chloroquine bisphosphate salt against the same strains. This unprecedented report opens new perspectives in both the fields of malaria chemotherapy and of surface-active ionic liquids derived from active pharmaceutical ingredients.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432003 | PMC |
| http://dx.doi.org/10.3390/ijms21155334 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Degradation of LiNiMnO Cathodes in the PFSI Ionic Liquid Electrolyte and Carbonate Electrolytes.
ACS Appl Mater Interfaces
September 2025
Department of Materials Science and Engineering, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway.
LiNiMnO (LNMO) is a promising material for the cathode of lithium-ion batteries (LiBs); however, its high operating voltage causes stability issues when used with carbonate battery electrolytes. Ionic liquids are a viable alternative to conventional carbonate solvents due to their thermal stability and electrochemical window. This work reports the performance of LNMO/Li half cells with an ionic liquid electrolyte (ILE) composed of 0.
View Article and Find Full Text PDFBridging electrostatic screening and ion transport in lithium salt-doped ionic liquids.
J Chem Phys
September 2025
Department of Chemistry Education and Graduate Department of Chemical Materials, Pusan National University, Busan 46241, Republic of Korea.
Alkali salt-doped ionic liquids are emerging as promising electrolyte systems for energy applications, owing to their excellent interfacial stability. To address their limited ionic conductivity, various strategies have been proposed, including modifying the ion solvation environment and enhancing the transport of selected ions (e.g.
View Article and Find Full Text PDFCationic, anionic, and global dynamics in 1-hexyl-3-methylimidazolium halide supercooled ionic liquids studied by 1H and 35Cl magnetic resonance and oscillatory shear rheology.
J Chem Phys
September 2025
Fakultät Physik, Technische Universität Dortmund, D-44221 Dortmund, Germany.
The dynamics of the different constituents of the ionic liquid 1-hexyl-3-methylimidazolium chloride (HmimCl) is investigated using nuclear magnetic resonance including chlorine relaxometry, line shape analysis, and proton-detected diffusometry, as well as frequency-dependent shear mechanical measurements. This combination of techniques is useful to probe the individual motions of the anions and the cations, and the sample's overall flow response. The 35Cl- dynamics appears to be close to the structural (or α-) relaxation as seen by rheology.
View Article and Find Full Text PDFPlasma-Driven Decomposition of HAN-Based Ionic Liquids.
ACS Omega
September 2025
Ming Hsieh Department of Electrical Engineering, University of Southern California, Los Angeles, California 90089, United States.
A nanosecond pulse transient plasma is employed to initiate and control the exothermic decomposition of ionic liquids, namely, a mixture of hydroxylammonium nitrate (HAN) and 1-ethyl-3-methylimidazolium ethyl sulfate [EMIM]/[EtSO], as well as some noncombustible ionic liquids. Here, the plasma is discharged in a cylindrical geometry with a coaxial center wire electrode. High voltage (20 kV) nanosecond pulses (20 ns) at various frequencies up to 10 kHz produce a plasma discharge in the ionic liquid that initiates its nonthermal decomposition.
View Article and Find Full Text PDFMarine chitin valorization by ionic liquids and deep eutectic solvents: Dissolution, green extraction and conversion.
Bioresour Technol
September 2025
Department of Polymer Materials and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang 550025, China; Technology Innovation Center for High-Efficiency Utilization of Bamboo-Based Biomass in Guizhou Province, Guiyang 550025, China. Electronic address:
Worldwide, marine shell waste generated from the seafood industry has emerged as a significant environmental challenge. Indeed, this shell waste represents an abundant source of various valuable products, particularly chitin. However, the extraction and subsequent processing of chitin are hindered by the inherently resistant structure of these chitin-rich feedstocks, coupled with strong hydrogen bonding between chitin chains.
View Article and Find Full Text PDF