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We report a two-photon responsive drug delivery system (DDS), namely, p-hydroxyphenacyl-naphthalene-chlorambucil (pHP-Naph-Cbl), having a two-photon absorption (TPA) cross-section of ≥20 GM in the phototherapeutic window (700 nm). Our DDS exhibited both AIE and ESIPT phenomena, which were utilized for the real-time monitoring of anti-cancer drug release.
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http://dx.doi.org/10.1039/d0cc01903h | DOI Listing |
J Am Chem Soc
September 2025
Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
Understanding how molecular aggregation influences nonlinear optical properties is essential for advancing organic fluorophores in imaging, sensing, and photonic applications. However, the relationship between the molecular aggregation and the magnitude of nonlinear two-photon absorption cross-section remains underexplored. Here, we systematically investigate the aggregation-dependent two-photon absorption properties of the fluorophore TPAPhCN by tuning the degree of aggregation.
View Article and Find Full Text PDFNeuropharmacology
September 2025
Department of Life Sciences, Ben-Gurion University of the Negev, 84105, Beer Sheva, Israel; Zelman Center for Brain Science Research, Ben-Gurion University of the Negev, 84105, Beer Sheva, Israel. Electronic address:
Norepinephrine (NE) is a key neuromodulator in the brain with a wide range of functions. It regulates arousal, attention, and the brain's response to stress, enhancing alertness and prioritizing relevant stimuli. In the auditory domain, NE modulates neural processing and plasticity in the auditory cortex by adjusting excitatory-inhibitory balance, tuning curves, and signal-to-noise ratio.
View Article and Find Full Text PDFCancer Res
September 2025
Morgridge Institute for Research, Madison, Wisconsin, United States.
Patient-derived cancer organoids (PDCOs) are a valuable model to recapitulate human disease in culture with important implications for drug development. However, current methods for rapidly and reproducibly assessing PDCOs are limited. Label-free imaging methods are a promising tool to measure organoid level heterogeneity and rapidly screen drug response in PDCOs.
View Article and Find Full Text PDFInt J Pharm
September 2025
Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Guangzhou Road 300, Nanjing, People's Republic of China; Engineering Research Center of Intelligent Theranostics Technology and Instruments, Ministry of Education, People's Republic of China. Electronic address:
Background: Ultrasound-assisted transdermal drug delivery, or sonophoresis, enhances skin permeability, offering a non-invasive alternative for drug administration. However, its clinical application remains limited because of an insufficient understanding of its underlying mechanisms and optimal parameters. This study investigates the factors influencing ultrasound-enhanced drug absorption and examines its biological effects on skin structures and HaCaT cells, providing a comprehensive analysis of its mechanisms.
View Article and Find Full Text PDFCell Rep
September 2025
Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA; The Phil & Penny Knight In
The dorsal striatum plays a critical role in action selection, movement, and sensorimotor learning. While action-specific striatal ensembles have been described, the mechanisms underlying their formation and evolution during motor learning remain poorly understood. Here, we employed longitudinal two-photon Ca imaging of dorsal striatal neurons in head-fixed mice as they learned to self-initiate locomotion.
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