Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The aim of this study was to synthesize, characterize, and evaluate degradation and biocompatibility of poly(lactic-co-glycolic acid) + hydroxyapatite/β-tricalcium phosphate (PLGA+HA/βTCP) scaffolds incorporating simvastatin (SIM) to verify if this biomaterial might be promising for bone tissue engineering. Samples were obtained by the solvent evaporation technique. Biphasic ceramic particles (70% HA, 30% βTCP) were added to PLGA in a ratio of 1:1. Samples with SIM received 1% (m/m) of this medication. Scaffolds were synthesized in a cylindric shape and sterilized by ethylene oxide. For degradation analysis, samples were immersed in phosphate-buffered saline at 37°C under constant stirring for 7, 14, 21, and 28 days. Nondegraded samples were taken as reference. Mass variation, scanning electron microscopy, porosity analysis, Fourier transform infrared spectroscopy, differential scanning calorimetry, and thermogravimetry were performed to evaluate physico-chemical properties. Wettability and cytotoxicity tests were conducted to evaluate the biocompatibility. Microscopic images revealed the presence of macro-, meso-, and micropores in the polymer structure with HA/βTCP particles homogeneously dispersed. Chemical and thermal analyses presented similar results for both PLGA+HA/βTCP and PLGA+HA/βTCP+SIM. The incorporation of simvastatin improved the hydrophilicity of scaffolds. Additionally, PLGA+HA/βTCP and PLGA+HA/βTCP+SIM scaffolds were biocompatible for osteoblasts and mesenchymal stem cells. In summary, PLGA+HA/βTCP scaffolds incorporating simvastatin presented adequate structural, chemical, thermal, and biological properties for bone tissue engineering.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1563/aaid-joi-D-19-00148 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mechanistic Insights into Cytokine Antagonist-Drug Interactions: A Physiologically Based Pharmacokinetic Modelling Approach with Tocilizumab as a Case Study.
Pharmaceutics
July 2025
Certara Predictive Technologies Division, Certara UK Limited, Sheffield S1 2BJ, UK.
Understanding interactions between cytokine antagonists and drugs is essential for effective medication management in inflammatory conditions. Recent regulatory authority guidelines emphasise a systematic, risk-based approach to evaluating these interactions, underscoring the need for mechanistic insight. Proinflammatory cytokines, such as interleukin-6 (IL-6), modulate cytochrome P450 (CYP) enzymes, reducing the metabolism of CYP substrates.
View Article and Find Full Text PDFMultifunctional bilayer wound dressing based on 3D-printed sodium alginate/gelatin hydrogel and polycaprolactone nanofibers for accelerating diabetic wound healing.
Int J Biol Macromol
July 2025
Nanomedicine Research Laboratories, Center for Materials Science (CMS), Zewail City of Science and Technology, 6th of October, Giza 12578, Egypt. Electronic address:
Millions of diabetic patients endure serious complications, particularly chronic wounds. Prolonged inflammation, oxidative stress, bacterial infection, and impaired vascularization are characteristics of the diabetic wound that impede tissue regeneration and result in inappropriate healing. Therefore, fabricating antioxidant, antibacterial, and anti-inflammatory wound dressing is highly desirable.
View Article and Find Full Text PDFKelp and Cartilage Acellular Matrix Hybrid Microgel Assembly Realizes Articular Cartilage Repair Via ROS Scavenging, Endogenous BMSC Recruitment and Chondrogenic Differentiation.
Adv Healthc Mater
July 2025
School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
Articular cartilage repair remains challenging due to the inherent poor self-healing capacity and acute inflammation resulting from the over expression of intracellular reactive oxygen species (ROS). Although microfracture is frequently used in practical surgery, the newborn cartilage always exhibits fibrosis, mainly attributed to the weak ROS scavenging and mismatched microenvironment that fails to induce chondrogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). Herein, a novel simvastatin (SIM)-incorporated kelp and cartilage acellular matrix hybrid (labeled as SIM@KACM/CACM) microgel assembly with enhanced ROS scavenging, endogenous BMSC recruitment, and chondrogenic differentiation capabilities is constructed to improve microfracture-based articular cartilage repair.
View Article and Find Full Text PDFPhoto-curable layered double hydroxide-hyaluronic acid-composite hydrogels with multifunctional properties for growth factor-free bone regeneration.
Int J Biol Macromol
June 2025
Department of Medical Science, Soonchunhyang University, Asan 31538, Republic of Korea; Department of Pharmaceutical Engineering, Soonchunhyang University, Asan 31538, Republic of Korea. Electronic address:
Bone regeneration is a highly complex process involving the coordinated interaction between osteogenic stem cells, the extracellular matrix (ECM), and osteoinductive signals, which are often challenged by bacterial interference. While bone prostheses incorporating growth factors such as bone morphogenetic proteins have been commercially successful, the therapeutic use of recombinant growth factors can lead to significant adverse clinical outcomes. Here, we present a photo-curable layered double hydroxide (LDH)-composite hydrogel, designed to incorporate multiple functionalities for bone regeneration without the need for exogenous growth factors.
View Article and Find Full Text PDF