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Amphiphilic di-cationic cyanostilbene derivatives with aggregation induced emission (AIE) features formed luminescent supramolecular polymers in aqueous media. They bind bio-polyanion heparin, a known anticoagulant, in a multivalent fashion through the formation of co-assemblies with highly enhanced greenish-yellow emission. Heparin detection in nanomolar concentrations in buffer and in medically relevant concentrations in human serum and plasma was achieved.
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http://dx.doi.org/10.1039/d0cc03644g | DOI Listing |
J Thromb Thrombolysis
September 2025
Central Laboratory of Yongchuan Hospital, Chongqing Medical University, No. 439, Xuanhua Road, Yongchuan District, Chongqing, 402160, China.
In vitro assessment of the inhibitory effect of antiplatelet drugs on platelet aggregation is frequently employed to guide personalized antiplatelet therapy in clinical practice. However, existing methods for detecting platelet aggregation rely heavily on high concentrations of exogenous agonists, which may obscure part of the inhibitory effect of antiplatelet drugs and lead to an underestimation of their effects. This study validates a novel analytical strategy for evaluating the effects of antiplatelet drugs by quantifying the microscopic three-dimensional morphological parameters of platelet aggregates formed through spontaneous aggregation on a glass surface.
View Article and Find Full Text PDFClin Neuroradiol
September 2025
Department of Neurology, Soroka Medical Center, Beer Sheva, Israel.
Purpose: Emergent intracranial stenting (EICS) has demonstrated efficacy in managing intracranial stenosis in patients undergoing mechanical thrombectomy (MT) for acute ischemic stroke. However, an optimal pharmacological regimen balancing thrombosis prevention and hemorrhagic risk following stent deployment remains undefined. This study aimed to assess the safety and efficacy of prophylactic low-dose intra-arterial Eptifibatide following EICS.
View Article and Find Full Text PDFCureus
August 2025
Department of Neurology, National Hospital Organization Disaster Medical Center, Tokyo, JPN.
Bacterial meningitis and infectious cavernous sinus thrombosis (CST) are both life-threatening central nervous system infections, often caused by sinusitis. While cerebrovascular complications are well-recognized in bacterial meningitis, their association with CST is rare. A 69-year-old man presented with a 19-day history of headache, followed by diplopia.
View Article and Find Full Text PDFAdv Healthc Mater
September 2025
David Price Evans Global Health and Infectious Diseases Group, Pharmacology & Therapeutics, Institute of Systems Molecular and Integrative Biology, University of Liverpool, Crown Street, Liverpool, L69 7BE, UK.
Early diagnosis of Alzheimer's disease (AD) is hindered by the high cost, complexity, and centralization of current diagnostic platforms such as enzyme-linked immunosorbent assay (ELISA) and single-molecule array (SIMOA). Here, an integrated point-of-care (PoC) biosensing platform is reported based on redox-active polyphenol red molecularly imprinted polymers (pPhR MIPs) deposited on highly porous gold (HPG) electrodes for the ultrasensitive, reagent-free detection of phosphorylated tau 181 (p-tau 181) in undiluted plasma and serum. The unique electrochemical interface combines the signal-enhancing properties of HPG with the redox functionality of pPhR, eliminating the need for external redox probes.
View Article and Find Full Text PDFN Engl J Med
September 2025
Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.
Background: Heparin-induced thrombocytopenia (HIT) is an immune-mediated platelet disorder caused by antibodies that target complexes of platelet factor 4 (PF4) and heparin. HIT has been characterized as a polyclonal immune response; however, studies of other rare anti-PF4 disorders have identified clonally restricted antibodies.
Methods: In this study, we investigated the clonality of pathogenic HIT antibodies.