Antiplasmodial Activity of Stem Bark Aqueous Extract in Mice Infected by .

Background: is used in Cameroon traditional medicine to treat malaria and related symptoms. However, its antiplasmodial efficacy is still to be established.

Objectives: The present study is aimed at evaluating the and antiplasmodial activity and the oral acute toxicity of the extracts.

Materials And Methods: Extracts were prepared from leaves and stem bark of , by maceration in distilled water, methanol, ethanol, dichloromethane (DCM), and hexane. All extracts were initially screened against the chloroquine-resistant strain W2 of to confirm its activity, and the most potent one was assessed in malaria mouse model at three concentrations (100, 200, and 400 mg/kg/bw). Biochemical, hematological, and histological parameters were also determined.

Results: Overall, 7 extracts showed antiplasmodial activity with IC ranging from 0.809 g/mL to 5.886 g/mL. The aqueous extract from the stem bark of (sb) was the most potent (IC = 0.809 g/mL) and was further assessed for acute toxicity and efficacy in -infected mice. sb was safe in mice with a median lethal dose (LD) higher than 2000 mg/kg of body weight. It also exerted a good antimalarial efficacy with ED of 69.50 mg/kg and had no significant effect on biochemical, hematological, and histological parameters.

Conclusion: The results suggest that the stem bark extract of possesses antimalarial activity.