Anti-onchocerca activity, toxicity and induced biochemical changes of and stem bark methanolic extracts in mice.

Human onchocerciasis has devastating pathological effects and the control relies on community directed treatment with ivermectin. However, ivermectin is only microfilaricidal and threatened by potential resistance in the parasite among other limitations. and , with reported antiparasitic activity, were tested for anti-onchocerca activity and toxicity.

In Vivo Antibacterial and Biochemical Effects of Leaf Extract in a Rat Model of Multidrug-Resistant Typhimurium.

The burden of infections remains high largely due to emergence of antibiotic-resistant strains. used in traditional medicine to treat bacterial infection has shown considerable antibacterial activity in several in vitro studies but has not been extensively investigated in vivo. The aim of this study was to assess the antibacterial activity of this plant in a rat model of a multidrug-resistant (MDR) strain as a potential alternative treatment.

Association of non-alcoholic fatty liver disease with glycemic control among patients with type 2 diabetes mellitus at Limbe Regional Hospital, Southwest, Cameroon.

Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by combinations of insulin resistance and insulin deficiency. Non-alcoholic fatty liver disease (NAFLD) is emerging as a public health problem worldwide and affects up to 70% of patients with T2DM. Although patients with T2DM have an increased risk of developing advanced liver disease compared to healthy individuals, varying prevalence rates of NAFLD among patients with T2DM, ranging from 34% to 94%, have been reported.

In Vitro Antibacterial Potential against Multidrug-Resistant , Cytotoxicity, and Acute Biochemical Effects in Mice of Leaf Extracts.

The treatment of infections is threatened by multidrug resistance necessitating the search for alternative treatments, such as from medicinal plants. There are several reports on the antibacterial activity of . This study assessed the activity against multidrug-resistant (MDR) and also the toxicity of the leaves of this plant.

Macrofilaricidal Activity, Acute and Biochemical Effects of Three Lichen Species Found on Mount Cameroon.

Onchocerciasis is a parasitic infection affecting a relatively small population globally but has very devastating pathological outcomes. Ivermectin and recently moxidectin are the only drugs approved for clinical management of the disease, both of which have several limitations. In particular, they are efficacious against microfilariae (microfilaricidal) with no activity against adult worms (nonmacrofilaricidal).

Microbial, phytochemical, toxicity analyses and antibacterial activity against multidrug resistant bacteria of some traditional remedies sold in Buea Southwest Cameroon.

Background: Traditional medicine remedies are commonly used for treatment of diverse ailments including bacterial infections. The activity against resistant bacteria and safety of some remedies sold as anti-infective treatments in market places in Buea, Southwest Cameroon were investigated as potential alternative treatment to counter increasing antibiotic resistance.

Methods: Ten remedies were purchased, their components documented and microbial load estimated.