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Article Abstract
A phytochemical investigation of the MeOH extract of the leaves and twigs of , a relict vulnerable coniferous species endemic to China, led to the isolation and characterization of 35 diterpenoids/norditerpenoids. Twenty of these are new, including 11 -kaurane-type (amentotaxins C-M, -, respectively), three icetexane-type [= 9(10→20)-abietane-type (amentotaxins N-P, -, respectively)], four -labdane-type (amentotaxins Q-T, -, respectively), and two isopimarane-type [amentotaxins U () and V ()] compounds. Their structures were elucidated on the basis of spectroscopic data, single-crystal X-ray diffraction, the modified Mosher's method, and electronic circular dichroism data analyses. Compounds - are rare 18-nor--kaurane-type diterpenoids featuring a 4β,19-epoxy ring. All the isolates were evaluated for their cytotoxic effects against a small panel of cultured human cancer cell lines (HeLa, A-549, MDA-MB-231, SKOV3, Huh-7, and HCT-116), and some of them exhibited cytotoxicities with IC values ranging from 1.5 to 10.0 μM.
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